PMID: 9547126Apr 18, 1998Paper

Effects of comorbidity and polypharmacy on the clinical usefulness of sertraline in elderly depressed patients: an open multicentre study

Journal of Affective Disorders
F J Arranz, S Ros

Abstract

Antidepressant therapy in the elderly age group is frequently complicated by medical comorbidity, polypharmacy and increased sensitivity to drug effects. A nonblind, noncomparative, observational, multicentre study over 8 weeks was conducted to assess the effectiveness and tolerability of sertraline (50-200 mg/day) in 1437 elderly depressed outpatients with a mean (S.D.) age of 68 (6.3) years (range 60-92) in routine clinical practise. Depressive symptoms were monitored using the Montgomery Asberg Depression Rating Scale (MADRS) at baseline and at weeks 2, 4, 6 and 8. The mean dose of sertraline at the final visit was 85.2 mg/day (48% of patients were given the initial dose throughout the study). At the end of the study, mean percentage change of MADRS score from baseline was 61% (P < 0.001). A > or = 50% decrease in MADRS score was obtained in 70% of patients. Sertraline was well tolerated. Side effects occurred in 23% of patients, although only 5.1% withdrew because of adverse events. There were no significant differences in the antidepressant effectiveness or occurrence of side effects when patients with and without concomitant pathologic conditions or with and without concurrent medications were compared. These findings ind...Continue Reading

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Citations

Sep 12, 2006·The Journal of Neuropsychiatry and Clinical Neurosciences·Daniel WeintraubMatthew B Stern
Jul 29, 2009·Harvard Review of Psychiatry·Zeina ChemaliGregory Fricchione
Feb 24, 2004·CNS Spectrums·David L Dunner

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