PMID: 46840Jan 1, 1975

Effects of complement depletion in experimental chagas disease: immune lysis of virulent blood forms of Trypanosoma cruzi

Infection and Immunity
D B BudzkoF Kierszenbaum

Abstract

In mice infected with virulent blood (trypomastigote) forms of Trypanosoma cruzi, complement depletion with cobra venom factor caused a marked exacerbation of the disease evidenced by significantly increased parasitemia levels and early mortality as compared with those of untreated infected animals. The effect was greater in mice receiving cobra venom factor on day 7 postinfection, i.e., at the time when the parasites had had time to localize and multiply in the tissues and appeared in the circulation in appreciable numbers. The possibility that complement participates in host defense against T. cruzi infection through a mechanism involving immune lysis was explored in vitro. T. cruzi trypomastigotes were found to undergo immune lysis in sera of patients with chronic Chagas' disease, in sera of immunized mice, and in solutions containing both immune mouse gamma globulin and a source of active complement. This phenomenon failed to take place either in the absence of complement or after complement inactivation by heat or utilizing complement inactivators. The lytic capacity of heated sera was restored by the addition of active complement to the system. During the immune lysis of T. cruzi blood forms, complement was activated in h...Continue Reading

References

Jan 1, 1979·Preparative Biochemistry·T I Mercado, K Katusha
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·A P Dalmasso
Jan 1, 1988·Parasitology Research·R L CardoniE L Segura
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·W MoscaA E Homsi
Jan 1, 1984·Revista Do Instituto De Medicina Tropical De São Paulo·M A Shikanai-YasudaC A Vaz
Mar 13, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L F UmekitaI Mota
Jan 9, 2016·PLoS Neglected Tropical Diseases·Paola Rosa LuzIara J Messias-Reason
Jun 3, 1977·Zeitschrift Für Parasitenkunde·O Zwisler
May 1, 1993·Parasite Immunology·H M LopezM B Sztein
May 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·U E Uche, T W Jones
Oct 20, 2011·The Journal of Parasitology·Ayoola Oladiran, Miodrag Belosevic
Jan 1, 1981·Experientia·A C Corsini, A Stelini
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·A U KrettliZ Brener

Related Concepts

Pathologic Cytolysis
Biochemical Pathway
Alkalescens-Dispar Group
Trypanosomiasis
Immune Sera
Tumor Lysis Syndrome
Chagas Disease Pathway
Phosphoglycerate Dehydrogenase Activity
Hemolytic Complement
Parasitemia