Effects of compound preparation of Cordyceps sinensis and Tripterygium hypoglaucum on survival time of pigskin after allogeneic transplantation

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Dai-Wei ChengZhen-Yu Gao

Abstract

To investigate the effects of compound preparation of Cordyceps sinensis and Tripterygium hypoglaucum (CSTHC) on survival time of grafted pigskin after allogeneic transplantation and its mechanism. The pigskin was treated with CSTHC solution before allogeneic transplantation, and CSTHC ointment was applied for external use on the grafted pigskin after skin transplantation. Cyclosporine A (CsA) and normal saline were served as control. The survival time, the appearance and the histomorphological changes of the grafted pigskin were observed. The histomorphological changes of testicles in pigs were also examined. The CD4 and CD8 expressions in the grafted pigskins were measured by immunohistochemical method. The white blood cell count in peripheral blood and the liver and renal functions were also examined. The survival time of the grafted pigskin in the CSTHC-treated group was (28.50+/-3.26)d, which was much longer as compared with (10.60+/-1.52)d in the untreated group (P<0.01). The survival time of the grafted pigskin in the CsA-treated group was (28.33+/-3.50)d, and there was no remarkable difference in the survival time of the grafted pigskin between the CsA-treated group and the CSTHC-treated group. The expressions of CD4 an...Continue Reading

References

Sep 1, 1999·Immunology·A W RowbottomE G Corley

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Citations

Sep 15, 2007·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yan SunShi-guang Shan
Oct 13, 2015·The Cochrane Database of Systematic Reviews·Tao HongJunming Fan
Oct 1, 2020·Journal of Biomolecular Structure & Dynamics·V SachithanandamRamesh Ramachandran

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