Effects of compounds from Kaempferia parviflora on nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha productions in RAW264.7 macrophage cells

Journal of Ethnopharmacology
Supinya Tewtrakul, Sanan Subhadhirasakul

Abstract

Kaempferia parviflora Wall. ex Baker, is one of the plants in the Zingiberaceae family, locally known in Thai as kra-chai-dam. The rhizome of this plant has been used for treatment of gout, apthous ulcer and abscesses. Since K. parviflora rhizomes have long been used for treatment of inflammation and possessed marked nitric oxide (NO) inhibitory activity (IC(50)=7.8microg/ml), we thus investigated the inhibitory activity of compounds isolated from this plant against lipopolysaccharide (LPS)-induced NO release in RAW264.7 cells. From bioassay-guided fractionation of K. parviflora, seven methoxyflavones were isolated from the hexane fraction and were tested for their anti-inflammatory effects. Among the isolated compounds, compound 5 (5-hydroxy-3,7,3',4'-tetramethoxyflavone) exhibited the highest activity against NO release with an IC(50) value of 16.1microM, followed by 4 (IC(50)=24.5microM) and 3 (IC(50)=30.6microM). Compound 5 was also tested on LPS-induced prostaglandin E(2) (PGE(2)) and tumor necrosis factor-alpha (TNF-alpha) releases from RAW264.7 cells. It was revealed that 5 showed appreciable inhibitory effect on PGE(2) release (IC(50)=16.3microM), but inactive on TNF-alpha (IC(50)>100microM). These findings may support ...Continue Reading

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Citations

May 3, 2014·AAPS PharmSciTech·Sarunya TuntiyasawasdikulBungorn Sripanidkulchai
Aug 30, 2014·Journal of Ethnopharmacology·Somruedee YorsinChaweewan Jansakul
Dec 11, 2014·Food Science & Nutrition·Susumu YoshinoTeruo Kawada
Dec 10, 2013·Photodermatology, Photoimmunology & Photomedicine·Ji-Eun ParkJae-Kwan Hwang
May 24, 2011·Journal of Ethnopharmacology·Wachirawadee MalakulOwen L Woodman
Dec 9, 2014·International Journal of Pharmaceutics·Sarunya TuntiyasawasdikulBungorn Sripanidkulchai
Jul 19, 2014·Bioscience, Biotechnology, and Biochemistry·Satoru HorigomeMichio Komai
Oct 4, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Surasak SaokaewNathorn Chaiyakunapruk
Sep 30, 2010·Phytotherapy Research : PTR·Patcharin Tep-AreenanMichael Randall
Aug 22, 2017·Journal of Natural Medicines·Hiroko KobayashiTsutomu Shimada
Sep 11, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Catheleeya MekjaruskulBungorn Sripanidkulchai
Oct 9, 2019·Nutrients·Abdelsamed I ElshamyMohamed-Elamir F Hegazy
Jan 16, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Dalin ChenDingsen Deng
Jul 13, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sunkyu LeeJae-Kwan Hwang

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