Effects of Compression Stockings on Elevation of Leg Lymph Pumping Pressure and Improvement of Quality of Life in Healthy Female Volunteers: A Randomized Controlled Trial

Lymphatic Research and Biology
Ryota SugisawaH Konno

Abstract

Lymph is pumped through the collecting lymphatic vessels by both intrinsic and extrinsic forces. The intrinsic pump relies on spontaneous lymphatic contraction, which generates the pumping lymph pressure (Plp). Among healthy people with daily leg edema, a considerable number of cases are accompanied with low leg Plp. Herein, a double-blinded controlled trial was conducted in healthy female volunteers with reduced leg Plp to compare the effectiveness of a 15-29 mmHg compression stocking (Stocking A) and a 8-16 mmHg stocking (Stocking B) on elevating Plp. Among 219 healthy female volunteers who underwent measurement of leg Plp, 80 participants (36.5%) had unilateral or bilateral legs with Plp < 20 mmHg (122 legs with Plp < 20 mmHg and 38 legs with Plp ≧ 20 mmHg). These 80 participants were assigned to wear either Stocking A (n = 40) or Stocking B (n = 40) for 16 weeks. Leg Plp was measured using indocyanine green fluorescence lymphography and an occlusion cuff technique while sitting. At 16 weeks, both Stockings A and B resulted in significantly elevated leg Plp, with the effect on elevating Plp being superior for Stocking A. Only Stocking A resulted in decreased prevalence of leg edema and improved Short Form-36 scores. Compress...Continue Reading

Associated Clinical Trials

Aug 17, 2020·Prof. Raffaele Serra, MD, Ph.D.

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Citations

Mar 28, 2017·Lymphatic Research and Biology·Katarzyna OchalekZbigniew Szygula
Apr 5, 2019·Circulation. Cardiovascular Imaging·Sheyanth MohanakumarVibeke Hjortdal
Aug 6, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Mohammad S RazaviJ Brandon Dixon
Apr 11, 2019·Polymers·Ying Xiong, Xiaoming Tao
May 1, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kiriko AbeMeigen Liu

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Software Mentioned

Excel
Statistical Package for the Social Sciences ( SPSS )

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