Effects of computer-assisted navigation versus conventional total knee arthroplasty on the levels of inflammation markers: A prospective study

PloS One
Shu-Jui KuoChih-Hsin Tang

Abstract

Total knee arthroplasty (TKA) is a well-established modality for the treatment of advanced knee osteoarthritis (OA). However, the detrimental effects of intramedullary reaming used in conventional TKA for distal femur cutting are of concern. Avoiding intramedullary reaming with the use of computer-assisted navigation TKA can not only provide superior prosthetic alignment, but also mitigate perioperative blood loss and the dissipation of marrow emboli. We quantified local and systemic concentrations of inflammation markers for both techniques. Forty-four participants undergoing computer-assisted navigation and 53 receiving conventional TKA for advanced knee OA were recruited between 2013/02/08 and 2015/12/09. Blood samples were collected from all participants at baseline then again at 24 and 72 hours postoperatively and analyzed by ELISA for interleukin 6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) and transforming growth factor beta 1 (TGF-β1); these markers were also measured in Hemovac drain fluid collected at 24 and 72 hours. Serum levels of IL-6, IL-10, TNF-α and TGF-β1(unit for all markers: pg/mL) were increased from baseline by smaller increments in the navigation TKA cohort compared with the conventional TKA group...Continue Reading

References

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Citations

Feb 12, 2021·BMC Musculoskeletal Disorders·Artit LaoruengthanaKrit Pongpirul
Nov 3, 2020·British Journal of Hospital Medicine·A A MaganF S Haddad
Jan 12, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Cristian AlettoNicola Maffulli
Apr 13, 2021·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Pramod KamalapathyQuanjun Cui
Dec 19, 2021·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Abhishek KumarHorng-Chaung Hsu

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Methods Mentioned

BETA
blood drawn
ELISA
total hip arthroplasty

Clinical Trials Mentioned

NCT03163888

Software Mentioned

Power
SPSS

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