Effects of conductive hearing loss on gerbil central auditory system activity in silence

Hearing Research
D L TucciD Durham

Abstract

Animal models of conductive hearing loss (CHL) show altered structure and function in the central auditory system (CAS), particularly following unilateral deprivation. Assessment of neuronal activity as measured by 2-deoxyglucose (2-DG) uptake following CHL has been reported by two groups of investigators, with different findings. Woolf and colleagues [Brain Res. 274 (1983) 119] found that 2-DG uptake increased in the cochlear nucleus ipsilateral to the CHL, while Tucci et al. [Laryngoscope 109 (1999) 1359] found a decrease in 2-DG uptake in the ipsilateral cochlear nucleus. One significant difference between the protocols in the two studies was that, in the first study, animals were maintained in silence following 2-DG injection, whereas in the Tucci et al. study, animals were exposed to sound. The current study was designed to replicate the protocol used by Woolf et al. Young adult gerbils underwent unilateral malleus removal with bilateral canal ligation (n=6) or a sham procedure (n=7) 48 h prior to 2-DG administration and sacrifice. Optical density measurements were made from CAS nuclei. 2-DG uptake decreased in the ipsilateral cochlear nucleus and contralateral inferior colliculus, and in nuclei of the superior olivary com...Continue Reading

References

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Citations

Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·Sarah C M Hogan, David R Moore
Dec 10, 2003·International Journal of Pediatric Otorhinolaryngology·David R MooreSarah C M Hogan
Jan 29, 2008·Cerebral Cortex·Vibhakar C KotakDan H Sanes
Jan 18, 2013·PloS One·Vibhakar C KotakDan H Sanes
Apr 6, 2011·Hearing Research·Dan H Sanes, Vibhakar C Kotak
Sep 29, 2004·The European Journal of Neuroscience·Carmen ValeDan H Sanes
Feb 22, 2012·Acta Oto-laryngologica·Robert V Harrison, Jaina Negandhi
May 30, 2016·Brazilian Journal of Otorhinolaryngology·Arash BayatFakher Rahim
Jan 6, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Denise A TuckerAllison D Todd
Feb 9, 2005·The Journal of Comparative Neurology·Verónica Fuentes-SantamariaCraig K Henkel
Aug 10, 2007·Journal of Neurophysiology·Timothy A JonesBen Bonham
Oct 10, 2003·Journal of Neurophysiology·Ben H BonhamChristoph E Schreiner
Aug 12, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Joachim SchmutzhardAnnelies Schrott-Fischer
May 31, 2013·Journal of Neurophysiology·Anne E TakesianDan H Sanes

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