Effects of consuming a high carbohydrate diet after eight weeks of exposure to a ketogenic diet.

Nutrition & Metabolism
Mary Ann HonorsK P Kinzig

Abstract

Ketogenic diets have been utilized for weight loss and improvement in metabolic parameters. The present experiments examined the effects of returning to a chow diet after prolonged ingestion of a ketogenic diet. Rats were maintained on chow (CH) or a ketogenic diet (KD) for 8 weeks, after which the KD rats were given access to chow only (KD:CH) for 8 additional weeks. Caloric intake, body weight, and plasma leptin, insulin and ghrelin were measured before and after the dietary switch. After 8 weeks of consuming a ketogenic diet, KD rats had increased adiposity and plasma leptin levels, and reduced insulin, as compared to CH controls. One week after the diet switch, fat pad weight and leptin levels remained elevated, and were normalized to CH controls within 8 weeks of the dietary switch. Switching from KD to chow induced a transient hypophagia, such that KD:CH rats consumed significantly fewer calories during the first week after the dietary switch, as compared to calories consumed by CH rats. This hypophagia was despite significantly increased plasma ghrelin in KD:CH rats. Finally, KD:CH rats developed hyperphagia over time, and during weeks 6-8 after the diet switch consumed significantly more calories per day than did CH-fed...Continue Reading

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Citations

Mar 16, 2012·Epilepsia·Jeanelle PortelliIlse Smolders
Aug 23, 2011·Epilepsy Research·Liu Lin Thio
Jun 13, 2015·International Journal of Endocrinology·Giuseppe CastaldoPaolo Sorrentino
May 9, 2014·Frontiers in Neurology·Carmela GiordanoGiuseppe Biagini
Apr 30, 2010·Endocrinology·Kimberly P KinzigSara L Hargrave
Feb 26, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Gerwyn MorrisBasant K Puri
Nov 15, 2020·Metabolites·Cassandra A A Locatelli, Erin E Mulvihill

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