Effects of continuous infusion of low-dose human atrial natriuretic peptide (hANP) on the lungs during cardiac surgery

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
Ikuko ShibasakiGo Tsuchiya

Abstract

The objective of this study was to determine the effects of a continuous infusion of low-dose hANP on the lungs during cardiac surgery in patients under cardiopulmonary bypass (CPB). We analyzed 30 consecutive cases of cardiac surgery performed at our hospital from 2007-2008. The patients were divided into a group that received hANP (hANP group) or a group that received saline and no hANP (N-hANP group). We measured various parameters before and after surgery using a PiCCO monitor. There were no differences in the preoperative characteristics between the groups, although urine volume during the operation was significantly greater in the hANP group. After surgery, there were no significant differences between the groups in cardiac output index (CI), global enddiastolic volume index (GEDVI), intrathoracic blood volume index (ITBI), pulmonary blood volume index (PBI), extravascular lung water index (ELWI) and pulmonary vascular permeability index (PVPI), total protein, and creatine. In contrast, interleukin-6 (IL-6) and renin were significantly lower, and albumin was significantly higher in the hANP group. We found that low-dose hANP during open cardiac surgery inhibited the secretion and plasma activity of IL-6 and renin. Althoug...Continue Reading

References

Jan 13, 1984·Biochemical and Biophysical Research Communications·K Kangawa, H Matsuo
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·I KishimotoD L Garbers
Aug 28, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira SezaiKazutomo Minami
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May 25, 2013·The Annals of Thoracic Surgery·Akira SezaiMotomi Shiono

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Citations

Oct 20, 2015·Journal of cardiology·Akira Sezai, Motomi Shiono
Sep 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motofumi KumazoeHirofumi Tachibana

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