Effects of continuous lumbar intrathecal infusion of leptin in rats on weight regulation

Neuroscience
Tony L YakshC P LeBel

Abstract

Intracranial leptin alters food consumption and body weight. To systematically characterize the effects of extended continuous spinal intrathecal delivery on such regulation, female rats received continuous lumbar spinal infusion (14 days) through catheters connected to osmotic minipumps of a vehicle or one of several doses of recombinant murine leptin (0.03-10 microg/day). The following observations were made. (1) Leptin resulted in a dose-dependent suppression in body weight and food consumption at doses above 0.3 microg/day. (2) Food consumption was initially reduced. Weight fell for 7 days and then plateaued at a level proportional to dose. (3) The ratio of food consumed to body weight was constant for control animals across the study. Leptin-infused rats slowed the initial fall in weight by increasing food consumption, such that the food to body weight ratio returned to that of control values. Rats were thus regulating food consumption to sustain body weight as defined by leptin dose. (4) On day 14, cisternal cerebrospinal fluid was obtained and leptin measured. Concentrations covaried in a log linear fashion with infusion dose. Body weight and food consumption covaried similarly with cisternal leptin concentrations across...Continue Reading

References

Oct 1, 1995·The Journal of Clinical Investigation·D S WeigleJ L Kuijper
Jul 28, 1995·Science·M A PelleymounterF Collins
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·R DevosP Burn
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·N LevinF de Sauvage
Feb 27, 1996·Biochemical and Biophysical Research Communications·R B LynnJ F Caro
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M Van HeekH R Davis
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J J HwaC D Strader
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R J SeeleyM W Schwartz
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A B FawziM P Graziano
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·W H YuS M McCann
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·H FeiJ M Friedman
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·J L HalaasJ M Friedman
Jun 1, 1997·Genetical Research·L Bünger, W G Hill
Mar 12, 1999·Physiology & Behavior·T WangC A Baile
Jun 9, 2000·Annual Review of Physiology·R S Ahima, J S Flier
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H F WildmanG P Smith
Jul 7, 2000·Frontiers in Neuroendocrinology·R S AhimaJ K Elmquist
Sep 21, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G A Bray
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy

❮ Previous
Next ❯

Citations

Apr 13, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H ShimizuM Mori
Feb 11, 2003·Journal of Cellular Biochemistry·Jan O Gordeladze, Janne E Reseland
Apr 12, 2015·Domestic Animal Endocrinology·M Szczesna, D A Zieba
Dec 18, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·K S RiganoH T Jansen

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

American Journal of Physiology. Endocrinology and Metabolism
Ruth B S Harris
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Michael F WiaterSue Ritter
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ruth B S HarrisW P Flatt
© 2022 Meta ULC. All rights reserved