Effects of Continuous Positive Airway Pressure on Lipidaemia and High-sensitivity C-reactive Protein Levels in Non-obese Patients with Coronary Artery Disease and Obstructive Sleep Apnoea

Heart, Lung & Circulation
Zhiwei HuangYi Tang

Abstract

The effect of obesity and medication on the relationship between obstructive sleep apnoea (OSA) and lipidaemia and systemic inflammation is not fully understood for various reasons. The aim of the present study is to determine the effects of 12 months of therapy with continuous positive airway pressure (CPAP) on lipid profiles and high-sensitivity C-reactive protein (hs-CRP) in non-obese patients with coronary artery disease (CAD) and OSA. We consecutively recruited 78 non-obese subjects with newly diagnosed CAD and moderate-to-severe OSA who were taking lipid-lowering medication. Patients were randomised to CPAP treatment or the control group. The patients' lipids and the hs-CRP level were measured at baseline and at follow-up. Seventy patients completed the study. The CPAP and control groups had similar characteristics at baseline. The mean duration of CPAP treatment was 4.2±1.1h/night. There was no significant difference in the lipids or hs-CRP levels at 12 months (both, P>0.05). The apnoea-hypopnoea index and Epworth Sleepiness Scale were significantly lower in the CPAP treatment group than in the control group (both, P<0.05). Continuous positive airway pressure treatment in non-obese patients with CAD and OSA who are takin...Continue Reading

References

Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
Dec 11, 1999·JAMA : the Journal of the American Medical Association·M VisserT B Harris
May 4, 2004·European Heart Journal·Steven R CoughlinJohn P H Wilding
Jul 6, 2004·The American Journal of Medicine·Antonia BarcelóAlvar G N Agustí
Nov 12, 2005·The New England Journal of Medicine·H Klar YaggiVahid Mohsenin
Dec 15, 2005·Heart, Lung & Circulation·Darren Mansfield, Matthew T Naughton
Mar 14, 2007·Atherosclerosis·Michael SaletuJosef Zeitlhofer
Jun 9, 2007·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerGeraldo Filho Lorenzi
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Jean-Philippe EmpanaPierre Ducimetiere
Dec 17, 2009·American Journal of Respiratory and Critical Care Medicine·Ferran BarbéUNKNOWN Spanish Sleep and Breathing Group
Aug 21, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Toshiki AkahoshiShu Hashimoto
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Sydney B MontesiJessie P Bakker
Jun 12, 2014·The New England Journal of Medicine·Julio A ChirinosAllan I Pack

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.