Effects of continuous use of probiotics before liver transplantation: A randomized, double-blind, placebo-controlled trial

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Michał GrątMarek Krawczyk

Abstract

Although there is increasing evidence for the benefits of probiotics in patients with liver diseases, data on the benefits of pre-LT administration of probiotics are lacking. The aim of this study was to evaluate the effects of continuous administration of probiotics before liver transplantation (LT) on pre- and post-transplant patient outcomes. In this randomized, double-blind, and placebo-controlled trial adult cirrhotic patients listed for LT received a 4-strain probiotic preparation or placebo daily from enrollment until LT. The primary outcome measures were postoperative mortality and infection rates. The secondary outcome measures were 5-day post-transplant aspartate and alanine aminotransferase activities, bilirubin concentration, and international normalized ratio; waiting-list mortality; pre-transplant Model for End-stage Liver Disease score and Child-Turcotte-Pugh class changes; and pre-transplant infections. A total of 55 patients were randomized. The 90-day postoperative mortality rates were 0% and 4.3% in the probiotic and placebo groups, respectively (p > 0.99). Patients receiving probiotics had significantly reduced 30-day (4.8% versus 34.8%, p = 0.02) and 90-day (4.8% versus 47.8%, p = 0.002) infection rates, lo...Continue Reading

Citations

Apr 28, 2018·Current Medical Research and Opinion·Jingzhou MuTonghui Ma
May 29, 2018·Pharmacotherapy·Margaret R JorgensonLuis A Fernandez
May 8, 2019·Microorganisms·Haripriya GuptaKi Tae Suk
Jul 2, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Caitlin M GibsonCrystal K Howell
Jul 30, 2019·F1000Research·Harald Brüssow
Feb 12, 2021·International Journal of Environmental Research and Public Health·Małgorzata MoszakPaweł Bogdański
Nov 21, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Stephan C BischoffMathias Plauth
May 7, 2021·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Ming MaWentao Jiang
Aug 1, 2021·Clinical Nutrition ESPEN·Kontham Kulangara VarshaKesavan Madhavan Nampoothiri
Aug 8, 2021·International Journal of Molecular Sciences·Łukasz Masior, Michał Grąt
Oct 13, 2021·Current Opinion in Organ Transplantation·Nikki Duong, Jasmohan Singh Bajaj
Mar 17, 2021·Transplantation·Isabel Campos-VarelaSalvador Augustin

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