Effects of contrast material on the metabolite ratios in single-voxel MR Spectroscopy of intraaxial brain tumors

Medical Hypotheses
Alpay AlkanAyse Aralasmak

Abstract

The purpose of our study was to determine whether the administration of contrast material affects the results of MR Spectroscopy (MRS) in different intraaxial brain tumors. Thirty-three patients (median range 46.72 ± 2.95, range 9-77) with intraaxial brain tumors underwent MRS before and 5 min after intravenous administration of gadolinium based contrast material at the standard dose of 0.1 mmol/kg (Gadodiamide or Gd-DOTA). Metabolite ratios (N-acetyl aspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, and NAA/Cho) were calculated. There was no significant difference between the pre and postcontrast MRS spectra as regards to NAA/Cr (p:0.4), Cho/Cr (p:0.2), and NAA/Cho (p:0.2) ratios obtained from the intraaxial brain tumors. Contrast material administration did not change the metabolite ratios of MRS. Contrast administration would be useful in guiding voxel localization in MRS evaluation of intraaxial brain tumors.

References

Jan 1, 1996·Life Sciences·B L MillerD J Jenden
Feb 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P E SijensM Oudkerk

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Citations

Oct 24, 2012·Magnetic Resonance Imaging Clinics of North America·Bum-soo Kim, Juan E Gutierrez

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