PMID: 7203927Nov 1, 1980Paper

Effects of contrast materials on left ventricular function

Investigative Radiology
C B Higgins


The effects of intracoronary administration of contrast materials were investigated in conscious and anesthetized dogs prepared with pressure gauges or catheters in the left ventricle for measuring aortic pressure (P), LVP, and dP/dt, and dimension crystals on opposing endocardial surfaces of the LV for measuring LV dimensions and its first derivative dD/dt (velocity of contraction). All contrast materials were tested at a concentration of 370 mg I/ml. Biphasic responses were observed with monomeric contrast materials; direct effects occurred within the first 10 seconds after injection, while secondary or indirect effects (reflex?) ensued near the end of the first 10 seconds or in the second 10-second period (Higgins, 1978). The standard sodium-containing monomeric contrast material caused decreases in LV peak systolic pressure (LVSP), peak dP/dt, dP/dt at an LVP of 40 mmHg (dP/dt40), peak -dP/dt, -dP/dt at an LVP of 50 mmHg (-dP/dt50), and dD/dt (Higgins, 1978, Newell, 1979). It caused increases in LV end-systolic and end-diastolic dimension. The decreases in -dP/dt (rate of relaxation) persisted during the second 10 seconds, when the parameter of LV contractile state had increased above control levels. Similar effects were ob...Continue Reading


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Jan 1, 1985·International Journal of Cardiac Imaging·R A VogelE R Bates
Jan 1, 1988·International Journal of Cardiac Imaging·R A Vogel
Sep 1, 1985·American Heart Journal·J A WisneskiD L Morris
May 1, 1986·Progress in Cardiovascular Diseases·P C HanleyH C Smith
Sep 1, 1985·Progress in Cardiovascular Diseases·G B Mancini, C B Higgins
Nov 1, 1983·Clinical Radiology·S J BarterA Maseri
Sep 5, 1989·The American Journal of Cardiology·P Dawson
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Nov 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·I K AdzamliJ A Leppo
Oct 1, 1986·British Heart Journal·S R UnderwoodD B Longmore
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