Effects of coronary artery reperfusion on myocardial infarct size calculated from creatine kinase

The Journal of Clinical Investigation
S F VatnerP R Maroko

Abstract

The effects of coronary artery reperfusion at 1 and 3 h after occlusion on infarct size (IS) in the conscious dog were compared with a second group of dogs that were not reperfused (24 h occlusion). Infarct size was calculated from creatine kinase (CK) appearing in blood samples (IS(s)) and myocardial CK depletion (IS(m)), and determined from gross and histological inspection of the pathological tissue (IS(p)). Under both conditions, IS(m) correlated well with IS(p). In dogs with 24-h coronary occlusions, IS(s) correlated well with IS(m) (IS(s) = 14.26 + 1.18 x IS(m), r = 0.92). In reperfused dogs, the relationship remained linear but was altered (IS(s) = 15.33 + 2.07 x IS(m), r = 0.89). The slope was significantly greater, P <0.05, than that observed for dogs that were not reperfused, suggesting that more CK appeared in serum per gram of infarct. Similarly, significantly different relationships were observed in the reperfused and nonreperfused dogs, when IS(s) was compared with IS(p). Moreover, the configuration of the serial blood CK curve was changed significantly by reperfusion. In dogs with a 24-h occlusion, CK rose gradually to a peak at 11.4+/-0.5 h. In dogs reperfused at 3 h, CK rose sharply at 3 h and reached a peak at...Continue Reading

References

Feb 1, 1975·The Journal of Clinical Investigation·S F VatnerJ A Swain
Jan 1, 1974·The American Journal of Cardiology·G F BresnahanB E Sobel
May 1, 1955·Circulation·C M AGRESSJ S LADUE

❮ Previous
Next ❯

Citations

Sep 1, 1983·The American Journal of Medicine·A G FreifeldB H Bulkley
May 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·W T HermensA van der Laarse
Apr 17, 1991·European Journal of Pharmacology·H TodtG Raberger
Apr 1, 1990·Journal of Pharmacological Methods·G KrumplG Raberger
Apr 1, 1991·Journal of the American College of Cardiology·P R Puleo, M B Perryman
Sep 2, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Giampaolo CerisanoDavid Antoniucci
Jun 26, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·K W WodzigW T Hermens
Oct 1, 1986·Clinical Biochemistry·M PanteghiniO Visioli
Jun 1, 1997·Clinical Biochemistry·A H Wu
Jun 1, 1983·Journal of the American College of Cardiology·G S HirsowitzS Goldstein
May 1, 1983·Journal of the American College of Cardiology·W GanzH J Swan
Dec 1, 1985·Journal of the American College of Cardiology·M C Fishbein
Nov 1, 1987·Journal of the American College of Cardiology·D A CoxE R Passamani
Mar 21, 1998·Journal of the American College of Cardiology·N Pérez-CastellanoJ L Delcán
Feb 1, 1988·British Heart Journal·C de ZwaanW T Hermens
Nov 9, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Luciano Babuin, Allan S Jaffe
May 3, 2012·Current Problems in Cardiology·Allan S Jaffe
Jun 28, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Lei WangBao Li
Jan 1, 1989·American Heart Journal·S R DevriesD R Abendschein
Jul 1, 1980·The American Journal of Cardiology·D C WarltierH L Brooks
May 1, 1987·Progress in Cardiovascular Diseases·A J MossC L Odoroff
Mar 1, 1988·Progress in Cardiovascular Diseases·F R Cobb, A Chu
Sep 1, 1983·The American Journal of Cardiology·C S RobertsR A Kloner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.