Effects of Crataegus microphylla on vascular dysfunction in streptozotocin-induced diabetic rats

Phytotherapy Research : PTR
Gökçe TopalB Sönmez Uydeş Doğan

Abstract

Vascular dysfunction plays a key role in the pathogenesis of diabetic vascular disease. In this study, we aimed to investigate whether chronic in vivo treatment of Crataegus microphylla (CM) extract in diabetic rats induced with streptozotocin (STZ, intraperitoneal, 65 mg/kg) preserves vascular function and to evaluate whether the reduction of inducible nitric oxide synthase (iNOS), proinflammatory cytokines, and lipid peroxidation mediates its mechanisms of action. Starting at 4 weeks of diabetes, CM extract (100 mg/kg) was administrated to diabetic rats for 4 weeks. In aortic rings, relaxation to acetylcholine and vasoreactivity to noradrenaline were impaired, whereas aortic iNOS expression and plasma tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), total nitrite-nitrate, and malondialdehite levels were increased in diabetic rats compared with controls. Chronic CM treatment significantly corrected all the above abnormalities in diabetic rats. In comparison, pretreatment of the aorta of diabetic rats with N-[3(aminomethyl) benzyl]-acetamidine, dihydrochloride (10(-5)  M), a selective inhibitor of iNOS, produced a similar recovery in vascular reactivity. These results suggest that chronic in vivo treatment of CM preser...Continue Reading

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Citations

Jan 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Jie WangBo Feng
Feb 3, 2016·Frontiers in Pharmacology·Sara S Al DisiAli H Eid
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Mar 11, 2020·Frontiers in Pharmacology·Min WuYu Cao
Nov 12, 2020·Natural Products and Bioprospecting·Tarawanti VermaNagendra Singh Chauhan
Apr 21, 2020·Current Pharmaceutical Design·Mervin Chávez-CastilloManuel Velasco

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