PMID: 8590250Jan 1, 1995Paper

Effects of cromakalim and nicorandil on intraocular pressure after topical administration in rabbit eyes

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
C H Chiang, C H Lin

Abstract

In the study two potassium channel activators, cromakalim and nicorandil, were investigated in rabbits using three different levels of intraocular pressures (IOPs), including alpha-chymotrypsin-induced ocular hypertension, hypotension (IOP recovery method) and normal tension. Cromakalim significantly increased IOP during the initial period in normotensive and hypotensive rabbits, but in the later time, reduced IOP in the alpha-chymotrypsin-induced model. Nicorandil had a similar but less potent effect. In addition, cromakalim also affected ocular blood flows, which had a trend to reduce blood flow about 2-3 hr later, after topical administration of the eyedrop. Two possible mechanisms for increasing IOP effect of potassium channel activators were: (a) enhancing the formation of aqueous humor; (b) relaxing the trabecular meshwork to reduce the outflow of aqueous humor.

References

Apr 1, 1991·Experimental Eye Research·J M WolosinT E Machen
Aug 22, 1989·European Journal of Pharmacology·C H GelbandC Van Breemen
Mar 1, 1974·American Journal of Ophthalmology·D Sears, M Sears
Nov 1, 1967·Archives of Ophthalmology·O J Lorenzetti, L F Sancilio

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Citations

Feb 27, 2004·European Journal of Pharmacology·Takashi KonnoNorimichi Nakahata
Jan 3, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sheng-Fu HuangChiao-Hsi Chiang
Oct 30, 2013·Journal of Clinical Bioinformatics·Sarah F JanssenArthur Ab Bergen
Feb 15, 2012·Clinical and Experimental Dermatology·S KamathK Bhagwandas
Aug 26, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·C H ChiangA R Lee
Jul 1, 2016·Taiwan Journal of Ophthalmology·Shital S PanchalDevdas D Santani

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