PMID: 8603796Jan 1, 1996Paper

Effects of crude garlic extract on mouse chromosomes in vivo

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T DasG Talukder

Abstract

Three concentrations (25, 50 and 100 mg/kg body weight) of fresh garlic (Allium sativum L.) were administered daily by gavage to Swiss albino mice for different durations up to 60 days. These concentrations had been observed to protect significantly against effects of known clastogens. The endpoints scored were frequencies of chromosomal aberrations and damaged cells induced in bone marrow preparations. These parameters were found to be directly dose dependent and after an initial enhancement at 7 days, were reduced following prolonged exposure for 30 and 60 days to the low level observed at 24 hr. Therefore, administration of a low concentration of garlic extract daily is suggested for at least 30 days to obtain the maximum benefit of the extract in protecting against the clastogenic effects of known genotoxicants.

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Citations

Jul 4, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K BanerjeeS K Maulik
Jun 1, 2011·Nutrition Research Reviews·S V RanaR P Ola
Nov 16, 2001·Asia Pacific Journal of Clinical Nutrition·S ArivazhaganA Ramesh
Oct 24, 2007·Scandinavian Journal of Immunology·M R Gamboa-LeónE Dumonteil
Jun 3, 2008·Cancer Letters·Nrashant SinghAnand P Sahu
Feb 26, 2003·Phytotherapy Research : PTR·S K BanerjeeS K Maulik
Jan 23, 2003·Nutrition Journal·Sanjay K Banerjee, Subir K Maulik
Feb 11, 2015·International Journal of Analytical Chemistry·Ashish GothwalVikas Hooda
Nov 15, 2017·Future Science OA·Ravindra M SamarthYoshihisa Matsumoto
Jan 1, 2007·Acta Medica (Hradec Králové)·Miroslav PohankaDaniel Jun
Sep 15, 2004·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Kothapa N. ChettySrikrishna N. Chetty

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