Effects of crude protein and lactose levels in diets on growth performance, intestinal morphology, and expression of genes related to intestinal integrity and immune system in weaned piglets

Animal Science Journal = Nihon Chikusan Gakkaihō
Marcos H SoaresAlysson Saraiva

Abstract

To evaluate the effects of crude protein (CP) and lactose (LAC) for weaned piglets on performance, intestinal morphology, and expression of genes related to intestinal integrity and immune system, 144 piglets with initial weight 7.17 ± 0.97 kg were allotted in a randomized design, in a 2 × 3 factorial arrangement (20.0% and 24.0% CP and 8.0%, 12.0%, and 16.0% LAC) with eight replicates. Piglets fed 20.0% CP had greater weight gain and feed intake. Including 12.0% LAC in the 20.0% CP diet provided higher villous height in the duodenum than 8.0% LAC, and 12.0% or 16.0% LAC in the 24.0% CP diet resulted in higher villous height in the jejunum and ileum, and higher villi/crypt ratio in the ileum than 8.0% LAC. No effects of CP and LAC on interleukin-1β and tumor necrosis factor-α mRNA were observed. The 16.0% LAC diet provided higher gene expression of transforming-β1 growth factor. Feeding 20.0% CP resulted in better performance than 24.0% CP. The 12.0% LAC diet promoted greater genetic expression of occludin and zonula occludens. Including 12.0% LAC in the diet may improve intestinal epithelial morphology and integrity, and these improvements are more evident when piglets are fed diets with 24.0% CP.

References

Oct 1, 1978·The American Journal of Clinical Nutrition·W J Visek
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A BarnardH L Moses
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 7, 2006·American Journal of Physiology. Endocrinology and Metabolism·Douglas G BurrinDarryl Hadsell
Feb 26, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Paolo AureliGian Vincenzo Zuccotti
May 2, 2013·Journal of Animal Science and Biotechnology·Joy M CampbellJavier Polo
Apr 1, 2015·Nature Reviews. Gastroenterology & Hepatology·Laure B BindelsJens Walter
Oct 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·David L SigaletJens Holst
Aug 25, 2018·Animal Nutrition·Yanhong LiuHans H Stein

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