Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Complementary Therapies in Medicine
Maryam Saberi-KarimianAmirhossein Sahebkar

Abstract

Nonalcoholic fatty liver diseases (NAFLD) is a highly prevalent disease that is closely associated with several cardiometabolic complications. The potential anti-inflammatory role of curcuminoids that have already been reported to reduce hepatic steatosis, in patients with NAFLD was explored in this study. This double-blind, randomized placebo-controlled trial was conducted for a period of 8 weeks in patients with NAFLD. Subjects (n = 55) were randomly allocated to receive either curcuminoids or placebo. The curcuminoids group received one capsule containing 500 mg curcuminoids (plus 5 mg piperine to increase intestinal absorption) per day for 8 weeks and the control group received matched placebo capsules for the same period. Liver ultrasonography was performed to assess the severity of hepatic steatosis at baseline and the study end. Serum levels of cytokines including interleukin-1α, interleukin-1β, interleukin-2, interleukin-4, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-α, monocyte chemoattractant protein-1, interferon γ, vascular endothelial growth factor and epidermal growth factor were measured before and after the intervention. The two groups were comparable in demographic features at baseline. ...Continue Reading

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Citations

Aug 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Olubanke O OgunlanaFranklyn N Iheagwam
Dec 1, 2020·Platelets·Paula Oneto, Julia Etulain
Feb 7, 2021·BioFactors·Seyede Atefe HosseiniAmirhossein Sahebkar
Jan 23, 2021·Antioxidants·Giovanni TossettaDaniela Marzioni
Nov 7, 2020·Phytotherapy Research : PTR·Babak AlikiaiiAmirhossein Sahebkar
Apr 16, 2021·Phytotherapy Research : PTR·Mohammad BagherniyaAmirhossein Sahebkar
Jul 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yaw-Syan FuChing-Feng Weng

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