Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury

The Journal of Thoracic and Cardiovascular Surgery
S LoganathanGábor Szabó

Abstract

Custodiol (histidine-tryptophan-ketoglutarate solution) is a leading organ preservation solution. On the basis of this solution, the novel Custodiol-N was developed. The present study investigated the effects of Custodiol-N in a rat model of heart transplantation. Heterotopic heart transplantation was performed in Lewis rats. Four groups were assigned: 2 Custodiol-N-treated groups and 2 Custodiol-treated control groups with a reperfusion time of 1 hour and 24 hours, respectively. Coronary blood flow, left ventricular pressure, its first derivative, left ventricular end-diastolic pressure, endothelium-dependent vasodilatation to bradykinin and endothelium-independent vasodilatation to sodium nitroprusside, and adenosine triphosphate content were measured. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining was performed to detect apoptotic cardiomyocytes. After 1 hour, coronary blood flow (3.99 +/- 0.24 mL/min/g vs 2.86 +/- 0.35 mL/min/g; P < .05), left ventricular pressure (117 +/- 18 mm Hg vs 82 +/- 4 mm Hg; P < .05), and first derivative of left ventricular pressure (3453 +/- 577 mm Hg/s vs 1740 +/- 116 mm Hg/s; P < .05) were significantly higher in the Custodiol-N group compared with the cor...Continue Reading

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Citations

Jan 17, 2014·Langenbeck's Archives of Surgery·Helge Bruns, Peter Schemmer
Dec 30, 2014·Interactive Cardiovascular and Thoracic Surgery·Sarkis M MinasianTimur D Vlasov
Jun 26, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Cora WexHans Lippert
Apr 19, 2015·Journal of Cardiothoracic Surgery·Gábor VeresGábor Szabó
Jan 17, 2015·The Journal of Surgical Research·Shiliang LiGábor Szabó
Jul 12, 2011·The Journal of Thoracic and Cardiovascular Surgery·Donna M Rudd, Geoffrey P Dobson
Oct 18, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Helena BedanovaPetr Nemec
Dec 24, 2019·Clinical and Experimental Pharmacology & Physiology·Nina FeirerAlexandro Hoyer
Aug 9, 2016·Current Opinion in Organ Transplantation·Franka MessnerStefan Schneeberger
Mar 23, 2018·Acta Pharmacologica Sinica·Lei JingMingyao Liu
Jan 23, 2019·Interactive Cardiovascular and Thoracic Surgery·Alexandro HoyerMaja-Theresa Dieterlen
Sep 10, 2020·International Journal of Molecular Sciences·Annika MohrFelix Becker
Nov 1, 2020·International Journal of Molecular Sciences·Viktorija ZitkutePeter Schemmer

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