PMID: 1709Dec 19, 1975

Effects of cyanide and doxapram during hypothermia

Pflügers Archiv : European journal of physiology
A V Ruiz


The ventilatory responses, blood gases and acid-base status to intravenous injections of KCN and doxapram hydrochloride were studied in anesthetized dogs during normothermia and at two levels of hypothermia. In the normothermic animal, KCN evoked significant elevations of minute and alveolar ventilations. For the mildly hypothermic (32-33 degrees C) dog, minute and alveolar ventilations were proportionally greater than for normothermia. Bolus infusions of KCN to deeply hypothermic dogs (28-29 degrees C) elicited larger and nearly similar increases of minute and alveolar ventilations as compared, respectively, with normothermia and mild hypothermia. Compared to their controls, injections of doxapram during normothermia, mild and deep hypothermia augmented VE 43.3%, 63.6% and 31.5%, respectively. With doxapram there was a feeble increase in alveolar ventilation. These results demonstrate that the peripheral (arterial) chemoreceptors preserve the capacity to respond to stimuli given acutely while lowering core temperature and in some circumstances this capacity is even enhanced as compared to normothermia.


Jul 21, 1975·Pflügers Archiv : European journal of physiology·A V Ruiz
Feb 11, 1971·The American Journal of Physiology·L JacobsJ H Comroe
May 1, 1971·The American Journal of Physiology·J A Krasney
May 1, 1966·Journal of Applied Physiology·J W Severinghaus
Feb 1, 1961·British Journal of Pharmacology and Chemotherapy·R BYCK
Mar 1, 1961·Archives internationales de physiologie et de biochimie·M TERZIOGLUF OZER


Jul 21, 1975·Pflügers Archiv : European journal of physiology·A V Ruiz
Dec 19, 1975·Pflügers Archiv : European journal of physiology·A V Ruiz

Related Concepts

Carbon Dioxide
Chemoreceptor Cells
Canis familiaris
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Hypothermia, Accidental

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Pflügers Archiv : European journal of physiology
A V Ruiz
Pflügers Archiv : European journal of physiology
A V Ruiz
Pflügers Archiv : European journal of physiology
A V Ruiz
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