PMID: 9189821Jun 15, 1997Paper

Effects of cyclical mechanical stress on the controlled release of proteins from a biodegradable polymer implant

Journal of Biomedical Materials Research
D M Arm, A F Tencer

Abstract

The availability of osteogenic proteins for orthopedic applications has led to great interest in developing delivery systems for these substances. Standard release rate models are applicable in most biological settings, but orthopedic implants usually bear mechanical loads. To determine whether a release rate model for load bearing applications must consider mechanical stress, the effects of dynamic mechanical stress on the in vitro release kinetics of two model proteins, bovine albumin (BA) and trypsin inhibitor (TI), from a biodegradable film were evaluated. Biodegradable poly(lacticco-glycolic acid) cylindrical implants with embedded proteins were subjected to cyclic three point bending loading of 720 cycles/day at 0.4 Hz for 2 weeks. Protein release into solution, swelling and mass loss changes, molecular weight degradation, and the presence of microstructural stress cracks and pores in the polymer carrier were evaluated. Cumulative BA and TI releases with time were significantly higher when a cyclic bending load was applied and increased with the magnitude of the load. Mass loss was not significantly greater, nor was swelling or molecular weight change of the polymer carrier in this 2-week interval. Pores on the surface of...Continue Reading

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Citations

Jul 11, 2007·Journal of Materials Science. Materials in Medicine·Manuela C C M SobralM H Gil
Jul 19, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hans GollwitzerAxel Stemberger
Nov 20, 2016·Advanced Drug Delivery Reviews·Julia WangMark W Grinstaff

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