PMID: 6413464Aug 1, 1983Paper

Effects of cyclooxygenase and lipoxygenase inhibition on lung fluid balance after thrombin

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
R BiziosA B Malik

Abstract

We examined the roles of the cyclooxygenase and lipoxygenase pathways in the alterations in lung fluid and protein exchange after pulmonary microembolism. Infusion of alpha-thrombin (T) (55 +/- 13 U/kg) immediately increased mean pulmonary arterial pressure (Ppa) and mean pulmonary vascular resistance (PVR), but both Ppa and PVR waned with time after T. Cyclooxygenase inhibition with either indomethacin or ketoprofen produced sustained increases in Ppa and PVR. The initial increases in Ppa in the cyclooxygenase-inhibited groups (CI) were matched to the control group by administering greater amounts of T. In the control group, T rapidly increased pulmonary lymph flow (Qlym) by two- to threefold, and this was associated with a steady increase in lymph-to-plasma protein concentration ratio (L/P). In contrast, in cyclooxygenase-inhibited (CI) groups, Qlym increased gradually to greater levels than in the control group, and L/P did not change. The effect on lung vascular permeability was determined by inflating a left atrial balloon catheter to raise pulmonary capillary pressure (Pc). An increase in Pc after T in the control group further increased Qlym and did not change L/P, whereas the increase in Pc after T in CI groups further ...Continue Reading

Citations

Dec 1, 1986·Journal of Cardiac Surgery·W J GreeleyW D Watkins
Jan 1, 1995·Upsala Journal of Medical Sciences·C M AhnT Saldeen
Jul 1, 1987·The American Review of Respiratory Disease·J G GarciaA B Malik
Jun 1, 1989·The American Review of Respiratory Disease·S I Said, H D Foda
Jan 1, 1985·Lung·A B MalikK E Burhop
Jan 1, 1985·Molecular Aspects of Medicine·A B Malik, S K Lo
Feb 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H W FarberF L Glauser

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