PMID: 6409930Jul 1, 1983Paper

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep

The Journal of Clinical Investigation
J R SnapperK L Brigham

Abstract

The effects of Escherichia coli endotoxin on lung mechanics, hemodynamics, gas exchange, and lung fluid and solute exchange were studied in 12 chronically instrumented unanesthetized sheep. A possible role for cyclooxygenase products of arachidonate metabolism as mediators of the endotoxin-induced alterations in lung mechanics was investigated by studying sheep before and after cyclooxygenase inhibition with sodium meclofenamate and ibuprofen. Sheep were studied three times in random order: (a) sodium meclofenamate (or ibuprofen) infusion alone; (b) E. coli endotoxin alone; and (c) meclofenamate (or ibuprofen) and endotoxin. Meclofenamate alone had no effect on any of the variables measured. Endotoxin alone caused early marked changes in lung mechanics: resistance to airflow across the lungs (RL) increased 10-fold, dynamic lung compliance (Cdyn) decreased 80% and functional residual capacity (FRC) decreased by greater than 30%. The alveolar-to-arterial oxygen difference (delta AaPO2) increased markedly following endotoxemia. In the presence of sufficient meclofenamate to inhibit accumulation of thromboxane-B2 and 6-keto-prostaglandin F1 alpha in lung lymph, endotoxin caused no increase in RL, Cdyn decreased by less than 40%, an...Continue Reading

References

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Nov 1, 1981·The Journal of Clinical Investigation·A C Heflin, K L Brigham

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Citations

Jan 22, 2002·Pediatric Pulmonology·Amir M KhanGiuseppe N Colasurdo
May 2, 1991·European Journal of Pharmacology·M C Dyson, P J Kadowitz
Mar 16, 1993·European Journal of Pharmacology·E WeitzbergJ M Lundberg
Feb 1, 1990·Prostaglandins·J Y TsangR R Schellenberg
Jan 1, 1988·Molecular Aspects of Medicine·N C OlsonC E McCall
Aug 1, 1987·Prostaglandins, Leukotrienes, and Medicine·E M Hardie, N C Olson
Oct 1, 1992·British Journal of Clinical Pharmacology·R A StoneR W Fuller
May 1, 1992·Journal of Veterinary Internal Medicine·C W Frevert, A E Warner
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·J R SnapperW Lu
Jun 1, 1989·The American Review of Respiratory Disease·S I Said, H D Foda
Jul 1, 1992·The American Review of Respiratory Disease·S KoyamaT Kobayashi
Jun 1, 1993·The American Review of Respiratory Disease·J R GossageJ R Snapper
Feb 1, 1993·American Journal of Respiratory Cell and Molecular Biology·S K Leeper-WoodfordA A Fowler
Nov 1, 1984·The Journal of Clinical Investigation·J R SnapperK L Brigham
Jan 1, 1992·Journal of Veterinary Internal Medicine·L O WhiteleyM S Kannan
Jan 1, 1984·Experimental Lung Research·J R Snapper, K L Brigham
Nov 1, 1986·The American Journal of the Medical Sciences·J E Millen, F L Glauser
Sep 1, 1984·The American Journal of the Medical Sciences·J H Newman, J R Sheller
Jan 1, 1991·Pulmonary Pharmacology·F L Watts, G R Bernard
Jan 1, 1988·Pulmonary Pharmacology·R R SchellenbergM M Glovsky
Jun 1, 1996·Clinics in Chest Medicine·L F Weikert, G R Bernard

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