PMID: 9545524Apr 18, 1998Paper

Effects of cyclopentenone prostaglandins and related compounds on insulin-like growth factor-I and Waf1 gene expression

Biochimica Et Biophysica Acta
T Bui, D S Straus

Abstract

The molecular pathways by which the cyclopentenone prostaglandins (PGA and PGJ series) inhibit cell growth and tumorigenicity are poorly understood. These cellular responses may be caused by specific regulation of growth-related and stress-induced genes. A variety of prostaglandins were tested for their ability to regulate insulin-like growth factor-I (IGF-I) and Waf1 gene expression in C6 rat glioma cells. The prostaglandins (in order of potency) PGJ2 > PGA1 > PGA2, approximately PGD2 > PGE2 all significantly repressed IGF-I gene expression. With the exception of PGE2, the same prostaglandins that repressed IGF-I also induced Waf1 gene expression. However, the order of potency for Waf1 induction was different than for IGF-I repression: PGA2 > PGA1 approximately PGJ2 > PGD2. The different order of potency of the prostaglandins in regulating IGF-I and Waf1 gene expression suggests that different intracellular signals may be involved in regulating the two genes. Augmentation of glutathione levels by pretreatment of cells with N-acetyl-L-cysteine attenuated the effect of PGA2 on IGF-I and Waf1 gene expression. conversely, depletion of the intracellular glutathione pool by pretreatment with buthionine sulfoximine potentiated the ef...Continue Reading

References

Sep 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Fukushima
Mar 3, 1992·Biochemical Pharmacology·J Parker, H Ankel
May 28, 1992·International Journal of Cancer. Journal International Du Cancer·C D'OnofrioE Bonmassar
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J TrojanJ Ilan
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C AmiciR I Morimoto
Mar 1, 1992·Experimental Cell Research·A M ChoiN J Holbrook
Sep 17, 1990·FEBS Letters·N MaruiM Fukushima
Feb 11, 1989·Nucleic Acids Research·A J FornaceE Lamoreaux
Feb 1, 1988·Archives of Biochemistry and Biophysics·M UjiharaO Hayaishi
Oct 1, 1968·The Biochemical Journal·E Boyland, L F Chasseaud
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·Y KikawaO Hayaishi
Dec 8, 1995·The Journal of Biological Chemistry·T RussoE Appella
Oct 13, 1995·The Journal of Biological Chemistry·K YuM A Lazar
Nov 15, 1994·Annals of the New York Academy of Sciences·M FukushimaS Fukushima
Oct 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M ChoiN J Holbrook
Apr 1, 1994·Anti-cancer Drugs·H Sasaki, M Fukushima
Apr 15, 1996·Genes & Development·R P BrunB M Spiegelman
Aug 23, 1996·Biochemical and Biophysical Research Communications·T FuseM Nakanishi
Dec 13, 1996·The Journal of Biological Chemistry·A RossiM G Santoro
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans

❮ Previous
Next ❯

Citations

May 3, 2005·The Journal of Steroid Biochemistry and Molecular Biology·William J AndrewsMichael P Schrey
Nov 14, 2002·Prostaglandins & Other Lipid Mediators·Ho-Shik KimIn-Kyung Kim
Apr 27, 2000·Proceedings of the Society for Experimental Biology and Medicine·B R LackeyD M Henricks
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D S StrausC K Glass
Apr 5, 2007·Cancer Cell International·S A Sharifah SakinahL P Azimahtol Hawariah
Mar 18, 2008·Chemistry and Physics of Lipids·Rafat A SiddiquiWilliam Stillwell
May 27, 2015·Bioscience, Biotechnology, and Biochemistry·Takahiro Shibata
Feb 7, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·B R LackeyD M Henricks
Sep 27, 2006·Anti-cancer Drugs·Matteo Conti
Jun 2, 2015·Organic & Biomolecular Chemistry·Remigiusz ŻurawińskiJulia Kaźmierczak-Barańska
Feb 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Miriam GranadoAsunción López-Calderón
Jan 12, 2002·The Journal of Biological Chemistry·Takahiro ShibataKoji Uchida
Sep 1, 2018·Journal of Experimental Botany·Daniel MaynardKarl-Josef Dietz
Apr 10, 1999·The Journal of Biological Chemistry·Y ChenL J Roberts
Apr 24, 2003·The Journal of Biological Chemistry·Takahiro ShibataKoji Uchida
Dec 18, 2009·Journal of the American Chemical Society·Satoru YamaguchiKoji Uchida
Dec 7, 2007·Chemical Research in Toxicology·Koji Uchida, Takahiro Shibata
Nov 24, 1999·Archives of Biochemistry and Biophysics·M AkagawaK Suyama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.