Effects of Cyclophosphamide Pulse Therapy on the Clinical and Histopathological Findings, Particularly Crescent Formation, in a Patient with Adult-onset Steroid-refractory Henoch-Schönlein Purpura Nephritis

Internal Medicine
Yusuke TanakaTakashi Shigematsu

Abstract

A 29-year-old woman was diagnosed with Henoch-Schönlein purpura nephritis (HSPN) based on the presence of purpura and histopathological findings showing crescent formation, mesangial proliferation and IgA deposition in the glomerular mesangium. She was treated with high-dose steroids; however, the nephritic syndrome persisted. Therefore, we diagnosed her with steroid-resistant HSPN and decided to add treatment with cyclosphamide pulse therapy. After one year of treatment, the histopathological findings, including crescent formation and IgA deposition, improved, as confirmed on a renal biopsy, and the patient fulfilled the criteria for complete remission. Cyclophosphamide pulse therapy may be considered an effective treatment for intractable HSPN.

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Citations

Nov 15, 2019·British Journal of Clinical Pharmacology·Guo-Xiang HaoWei Zhao
Oct 13, 2019·Clinical and Experimental Nephrology·Jingjing ChenShao Liu
Dec 8, 2020·Clinical & Translational Immunology·Takashi ImaiShouichi Ohga

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