Effects of cyclosporin A on hepatitis C virus infection in bone marrow transplant patients. Bone Marrow Transplantation Team

Bone Marrow Transplantation
H AkiyamaMichinori Kohara

Abstract

The hepatitis C virus (HCV) infection has, in general, been considered not to affect liver function severely during the course of bone marrow transplantation (BMT) except for late hepatitis which coincided with a decrease in immunosuppressive therapy. We examined serial sera of two patients with positive HCV antibody who underwent allogeneic BMT and found that while the dose of cyclosporin A tapered off, the serum concentration of HCV core protein increased before the occurrence of hepatitis. This suggests that viral reactivation and growth might be one of the important mechanisms of hepatitis after BMT in patients with positive HCV antibody.

Citations

Mar 20, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (RKI)
Nov 9, 2000·Pediatric Neurology·A K Al-RasheedS K Weiss
Jan 25, 2012·Nature Reviews. Clinical Oncology·Harrys A Torres, Marta Davila
Apr 22, 2009·The Journal of Biological Chemistry·Udayan ChatterjiPhilippe Gallay
Aug 5, 2008·The Keio Journal of Medicine·Mitsuyasu NakamuraToshifumi Hibi
Sep 21, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Malcolm M WellsBandar M Aljudaibi
Oct 21, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J L PiñanaC Solano
Nov 28, 2012·Clinics in Liver Disease·Fernando E MembrenoEric J Lawitz
Jul 17, 2010·Journal of the American Academy of Dermatology·Vito Di Lernia, Giuseppe Albertini
Feb 6, 2010·Journal of Virological Methods·Helen WallerPaul Targett-Adams
Jul 25, 2009·Clinics in Liver Disease·Philippe A Gallay
Jun 19, 2009·Journal of the American Academy of Dermatology·Bruce StroberMelodie Young
Oct 16, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Stephen Pollard
Oct 4, 2005·Alimentary Pharmacology & Therapeutics·F FabriziP Martin
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Koichi WatashiKunitada Shimotohno
Nov 29, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tsunamasa Watanabe, Yasuhito Tanaka
Sep 8, 2012·Biochimica Et Biophysica Acta·Leiyun WengTetsuya Toyoda
Apr 20, 2004·Bone Marrow Transplantation·C A P IvantesR Pasquini
Jun 19, 2003·Oncogene·Michal Oskar NowickiTomasz Skorski
Nov 3, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J-P LiuW-Z Ho
May 4, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J K WhitmireR Ahmed

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