Effects of cytokines combined with high-dose gamma irradiation on the expression of major histocompatibility complex molecules and intercellular adhesion molecule-1 in human ovarian cancers

International Journal of Cancer. Journal International Du Cancer
A D SantinG A Granger

Abstract

Tumor cells from 7 freshly isolated human ovarian tumors and 2 continuous human ovarian cancer cell lines were analyzed for their surface expression of MHC class-1, class 11 and ICAM-1 surface antigens before and after exposure to gamma-irradiation and/or the cytokines TNF-alpha plus IFN-gamma. All 7 fresh tumors expressed high levels of MHC class 1 and 1CAM-1 antigens, and levels were markedly up-regulated after exposure to TNF-alpha plus IFN-gamma Similarly, class-11 antigens were either induced (3 out of 7 tumors) or significantly up-regulated by TNF-alpha plus IFN-gamma. Exposure to high doses of gamma-irradiation also increased the expression of MHC class-1 and ICAM-1 antigens, albeit to a modest degree. MHC class 1 and ICAM-1 antigens expression was much lower on continuous human ovarian cell lines than on the fresh tumors. Exposure of these cells to TNF-alpha plus IFN-gamma markedly up-regulated antigen expression to levels comparable to those expressed on the freshly isolated tumors. With the established ovarian cell lines, removal of cytokines caused a rapid down-regulation of antigen expression to basal levels within 6 days, while in the fresh tumors a low level of up-regulation was still present at this time. In cont...Continue Reading

References

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Citations

Jun 14, 2014·PloS One·Romana KoppensteinerKonstantin J Dedes
Sep 5, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kelly J McKelveyConnie I Diakos
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Phil RollandIan Spendlove
Jan 27, 2021·Cancers·Dongli LiuCaroline E Ford
Jan 9, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T KordbachehT Illidge

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