Effects of CytoReductive surgery plus hyperthermic IntraPEritoneal chemotherapy (HIPEC) versus CytoReductive surgery for ovarian cancer patients: A systematic review and meta-analysis

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Yizi WangXiaoxin Ma

Abstract

The effects of Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) and CytoReductive Surgery (CRS) for ovarian cancer patients remain controversial. A systematic review and meta-analysis was conducted using PubMed, Embase and Web of Science databases to investigate Overall Survival (OS), Disease Free Survival (DFS) and adverse effects between HIPEC and CRS group. In our overall analysis (13 studies), patients in the HIPEC group exhibited a significantly improved OS (HR = 0.56, 95% CI = 0.41-0.76, P < 0.01) and DFS (HR = 0.61, 95% CI = 0.48-0.77, P < 0.01). Subgroup analysis revealed improved OS (HR = 0.57, 95% CI = 0.40-0.83, P = 0.04) and DFS (HR = 0.61, 95% CI = 0.47-0.80, P < 0.01) for primary ovarian cancer in favour of HIPEC group. However, recurrent ovarian cancer patients who received HIPEC exhibited only significantly improved OS (HR = 0.48, 95% CI = 0.24-0.96, P < 0.01) but not DFS (HR = 0.59, 95% CI = 0.33-1.08, P = 0.09). In addition, both significantly improved OS and DFS were also observed in patients who received HIPEC in the subgroups based on the following factors: studies published before 2015, studies with ≥100 total patients, a single drug used for HIPEC, 90-min HIPEC duration and a regimen of CRS plus HIPEC fo...Continue Reading

Citations

Jul 12, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Qian LiPing Mo
Jun 4, 2020·Expert Opinion on Pharmacotherapy·Eelco de Bree, Dimosthenis Michelakis
Jul 18, 2020·Current Opinion in Oncology·Jan B VermorkenAlison Brand
Apr 3, 2020·World Journal of Surgical Oncology·Xiao Wang, Tianzuo Li
Aug 22, 2020·Pleura and Peritoneum·Christos IavazzoPaul Sugarbaker
Jul 28, 2020·The Journal of Obstetrics and Gynaecology Research·Hideaki TsuyoshiYoshio Yoshida
Dec 8, 2019·Clinical & Experimental Metastasis·Cascales Campos Pedro AntonioUNKNOWN Spanish Peritoneal Surgical Oncology Group (GECOP)
Jan 7, 2021·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Rhonda Farrell, Michael Burling
Nov 24, 2021·Annals of Surgical Oncology·Cascales Campos Pedro AntonioGil Martínez José

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