Effects of D- and L- enantiomers of adenosine, AMP and ADP and their 2-chloro- and 2-azido- analogues on human platelets

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
N J CusackG V Born

Abstract

Aggregation of human platelets by ADP and the inhibition of this effect by adenosine are apparently mediated by different receptors. One of the criteria for receptors is that they show stereospecificity for their ligands. We have synthesized L-enantiomers of D-adenosine, AMP and ADP, together with their corresponding photolysable 2-azido analogues so that platelet receptors could be tested for stereospecificity. All of the L-enantiomers were completely inactive as aggregators or inhibitors of platelet function. None of the L-enantiomers changed levels of platelet cAMP. 2-Azido-L-adenosine, AMP and ADP are proposed as useful controls in photoaffinity experiments for non-specific labelling.

References

May 18, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·N J Cusack, G V Born
Jul 20, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·N J Cusack, G V Born

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Citations

Jan 1, 1994·Pharmacology & Therapeutics·M P Abbracchio, G Burnstock
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Mar 1, 1981·British Journal of Pharmacology·N J Cusack, S M Hourani
Jan 1, 1982·British Journal of Pharmacology·C BrownC J Moody
Feb 1, 1985·British Journal of Pharmacology·G BurnstockL A Meldrum
Aug 1, 1983·British Journal of Pharmacology·G BurnstockP Meghji
Aug 12, 2015·Purinergic Signalling·Geoffrey Burnstock
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·R N Puri, R W Colman
Oct 1, 1985·American Journal of Medical Genetics·A R RhodesB R Korf
Jun 1, 1981·British Journal of Pharmacology·N J Cusack, S M Hourani
Jan 1, 1990·Annals of the New York Academy of Sciences·N J Cusack, S M Hourani

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