PMID: 6410439Jan 1, 1983Paper

Effects of d-amphetamine and morphine on discrimination: signal detection analysis and assessment of response repetition in the performance deficits

Psychopharmacology
W Koek, J L Slangen

Abstract

Signal detection analysis was used to examine the effects of d-amphetamine and of morphine on auditory discrimination in female rats. The probability of response repetition in the discrete trial two-choice discrimination procedure was used as an additional behavioral measure. d-Amphetamine (0.4-3.2 mg/kg) and morphine (1.88-15.0 mg/kg) decreased the sensitivity measures (A' and SI) but did not consistently affect the response bias measures (B" and RI). The probability of response repetition was increased by d-amphetamine and was not affected by morphine. It is concluded that the response bias measure B", derived from signal detection theory, and the empirical response bias measure RI, do not discriminate between the different ways in which d-amphetamine and morphine affect discriminative responding, under the conditions of this study.

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Citations

Mar 25, 2011·Psychopharmacology·Matthew A AlbrechtFlavie Waters
Nov 25, 1983·European Journal of Pharmacology·D Gilbert, S J Cooper
Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·D M Thompson, J M Moerschbaecher
Nov 1, 1986·Pharmacology, Biochemistry, and Behavior·I WeinerO Ben-Shahar
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·I WeinerJ Feldon
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J FeldonI Weiner
Aug 1, 1989·Pharmacology, Biochemistry, and Behavior·D M GrillyT W Grogan
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·R D HienzJ V Brady
Dec 13, 1991·Behavioural Brain Research·P J Reading, S B Dunnett
Apr 1, 2008·Dementia and Geriatric Cognitive Disorders·Jared M BruceGeoffrey Tremont

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