PMID: 1208622Sep 1, 1975Paper

Effects of d-amphetamine and scopolamine on activity before and after shock in three mouse strains

Pharmacology, Biochemistry, and Behavior
H AnismanL Kokkinidis

Abstract

In three experiments the following results were obtained: (a) Activity was greater both prior to and following exposure to shock among C57BL/6J mice than in DBA/2J mice, which in turn was greater than that of A/J mice. (b) Scopolamine hydrobromide increased general activity in DBA/2 and A mice, but had either no effect or decreased activity in the C57BL/6 strain. Following exposure to shock, however, the disinhibitory effects of scopolamine were apparent in all three strains. (c) d-amphetamine increased activity in all three strains. Moreover, following the single shock d-amphetamine had excitatory effects among both A and DBA/2 mice such that activity exceeded the level observed with d-amphetamine alone. Following several shock presentations a small but significant excitation was observed in C57BL/6 mice as well. Data were interpreted in terms of disinhibitory and excitatory effects of scopolamine and d-amphetamine, respectively, as well as possible interactions between the catecholaminergic and cholinergic systems. In addition, implications for sources of strain differences in avoidance behavior are discussed.

References

Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·H Anisman
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Citations

Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·H Anisman
Jul 1, 1975·Pharmacology, Biochemistry, and Behavior·H Anisman
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·A SmolenA C Collins
Apr 1, 1997·Progress in Neurobiology·S Puglisi-Allegra, S Cabib
Dec 8, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Todd D GouldHusseini K Manji
Feb 9, 2010·Pharmacology, Biochemistry, and Behavior·Scott E BowenSusan Irtenkauf
Jan 22, 2008·Neuroscience and Biobehavioral Reviews·Tamara J PhillipsJeanna M Wheeler
Oct 7, 2015·Frontiers in Neuroscience·Tamara J Phillips, Shkelzen Shabani
Jun 11, 2019·Frontiers in Molecular Neuroscience·Cory ParksMegan K Mulligan
Oct 18, 2014·Learning & Memory·Natalia C ColettisDiana A Jerusalinsky

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