Effects of d-amphetamine in grouped versus isolated humans

Pharmacology, Biochemistry, and Behavior
H De WitL H Brauer

Abstract

This study was designed to determine whether the subjective, behavioral or physiological effects of a stimulant drug in humans depend on whether subjects are tested under isolated or social conditions. Forty-two subjects were randomly assigned to either the Social (SOC) or Isolated (ISO) condition. SOC subjects participated in 4 h laboratory sessions in groups of 3 or 4, whereas ISO subjects participated in the sessions alone. All subjects participated in three sessions, during which they received capsules containing d-amphetamine (10 or 20 mg) or placebo, in mixed order under double blind conditions. Subjective, physiological and behavioral measures were obtained at regular intervals, d-amphetamine produced dose-related, prototypic stimulant effects on many measures, including self-reported mood states, behavioral indices and physiological measures. Most of these effects were unaffected by the setting in which subjects were tested (SOC vs ISO). However, body temperature was overall higher in the SOC group, and there was a trend for d-amphetamine to produce greater hyperthermic effects in the SOC group. In addition, 10 mg d-amphetamine increased heart rate in the SOC group but not in the ISO group. The results suggest that, lik...Continue Reading

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Citations

Sep 21, 2001·Physiology & Behavior·S JacobM K McClintock
Mar 14, 2000·Hormones and Behavior·S Jacob, M K McClintock
May 29, 2013·Psychopharmacology·Matthew G Kirkpatrick, Harriet de Wit
Apr 25, 2012·Psychopharmacology·Margaret C WardleHarriet de Wit
Mar 19, 2014·Psychopharmacology·Matthew G KirkpatrickHarriet de Wit
May 18, 2005·Alcoholism, Clinical and Experimental Research·Frances H Gabbay
Jan 24, 2007·Biological Psychiatry·Andrea DlugosHarriet de Wit
Aug 27, 2016·Journal of Psychopharmacology·Anya K BershadHarriet de Wit
Oct 5, 2014·Psychopharmacology·Matthew G Kirkpatrick, Harriet de Wit

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