Effects of d-amphetamine on temporal distributions of schedule-induced polydipsia

Pharmacology, Biochemistry, and Behavior
P Flores, Ricardo Pellón

Abstract

Food-deprived rats were divided into four groups according to the equal interval and time durations of a multiple fixed-interval, fixed-time schedule (15, 30, 60, and 120 s). Fixed-time components were signaled by a tone and lever withdrawal. d-Amphetamine (0.25-4.0 mg/kg) produced similar dose-dependent reductions in the drinking and licking induced by fixed-interval and fixed-time schedules. These dose-dependent decrements were a function of the interfood interval length. More licks occurred early in the interfood intervals with doses of d-amphetamine. Dose-dependent shifts to the left were observed in the distribution of licking, and there were dose-dependent decreases in the quarter-life, which were a function of fixed-interval and fixed-time lengths. The maximum lick rate within interfood intervals occurred at about the same absolute time in schedules up to 60 s; therefore, the effects of d-amphetamine were not mediated by its effects on temporal discrimination.

Citations

Aug 17, 2019·Frontiers in Behavioral Neuroscience·Tomek J Banasikowski, Emily R Hawken
Oct 15, 2013·Journal of the Experimental Analysis of Behavior·José Luis Castilla, Ricardo Pellón
Dec 29, 2012·Learning & Behavior·Ricardo Pellón, Angeles Pérez-Padilla
Mar 20, 2003·Psychopharmacology·Angeles Pérez-Padilla, Ricardo Pellón
Apr 14, 2005·Learning & Behavior·Ginesa López-CrespoPilar Flores

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