Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Maria J IuornoJohn E Nestler

Abstract

To determine whether the administration of D-chiro-inositol, a putative insulin-sensitizing drug, would affect the concentration of circulating insulin, the levels of serum androgens, and the frequency of ovulation in lean women with the polycystic ovary syndrome. In 20 lean women (body mass index, 20.0 to 24.4 kg/m 2) who had the polycystic ovary syndrome, treatment was initiated with either 600 mg of D-chiro-inositol or placebo orally once daily for 6 to 8 weeks. We performed oral glucose tolerance tests and measured serum sex steroids before and after therapy. To monitor for ovulation, we determined serum progesterone concentrations weekly. In the 10 women given D-chiro-inositol, the mean (+/- standard error) area under the plasma insulin curve after oral administration of glucose decreased significantly from 8,343 +/- 1,149 mU/mL per min to 5,335 +/- 1,792 mU/mL per min in comparison with no significant change in the placebo group (P = 0.03 for difference between groups). Concomitantly, the serum free testosterone concentration decreased by 73% from 0.83 +/- 0.11 ng/dL to 0.22 +/- 0.03 ng/dL, a significant change in comparison with essentially no change in the placebo group (P = 0.01). Six of the 10 women (60%) in the D-chi...Continue Reading

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References

Apr 1, 1987·Radiology·H C YehJ C Thornton
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·R J ChangS A Kaplan
Sep 28, 1995·The New England Journal of Medicine·S Franks
Apr 16, 1998·European Journal of Endocrinology·R Pasquali, M Filicori
Apr 16, 1998·European Journal of Endocrinology·E Diamanti-KandarakisA Bergiele
Jun 25, 1998·The New England Journal of Medicine·J E NestlerR Pasquali
Apr 29, 1999·The New England Journal of Medicine·J E NestlerG Allan

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Citations

Jul 10, 2009·The British Journal of Nutrition·Xiaobo LinRichard E Ostlund
Apr 1, 2008·Human Reproduction·Jean-Patrice BaillargeonEvanthia Diamanti-Kandarakis
May 1, 2007·Women's Health·Ephia Yasmin, Adam H Balen
Dec 20, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alfonsa PizzoLuisa Barbaro
Jul 16, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John E Nestler, Vittorio Unfer
Jun 4, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arturo BevilacquaZdravko A Kamenov
Nov 8, 2015·Reproductive Toxicology·Carlo AlviggiGiuseppe De Placido
Jun 5, 2012·The Journal of Nutritional Biochemistry·Marine L CrozeChristophe O Soulage
Mar 2, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cristiana PaulDavid M Brady
May 12, 2007·Journal of Reproductive Immunology·Marco SciosciaThomas W Rademacher
Jul 22, 2014·Journal of Clinical Pharmacology·Simona DinicolaMariano Bizzarri
Apr 28, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Arturo Bevilacqua, Mariano Bizzarri
Oct 27, 2015·Journal of Analytical Methods in Chemistry·Carmelo CorsaroNicola Cicero
May 30, 2015·Bioscience, Biotechnology, and Biochemistry·Shogo TsujiKen-ichi Yoshida
Oct 1, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antonio La MarcaAntonio Cianci
Sep 27, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zdravko KamenovAlessandro D Genazzani
Jan 18, 2012·Revista da Associação Médica Brasileira·Ione Maria Ribeiro Soares LopesJosé Maria Soares
Jul 14, 2016·European Journal of Medicinal Chemistry·P M RendleK M Loomes
Oct 1, 2016·International Journal of Endocrinology·Giovanna MuscogiuriFrancesco Orio
Sep 7, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ewa M MilewskaAlessandro D Genazzani
Oct 13, 2016·Indian Journal of Endocrinology and Metabolism·Bharti KalraJ B Sharma
Oct 9, 2016·Reproductive Biomedicine Online·Alessandro D Genazzani
Nov 1, 2016·International Journal of Endocrinology·Deepika Garg, Reshef Tal
Nov 30, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Giovanni MonastraMariano Bizzarri
Oct 24, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Enrico PapaleoAugusto Ferrari
Mar 13, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Emanuela RaffoneVincenzo Benedetto
May 26, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·J PundirS Thangaratinam
Jul 29, 2017·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Nov 28, 2017·BMC Complementary and Alternative Medicine·Susan ArentzAlan Bensoussan
Jan 9, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antoaneta GatevaZdravko Kamenov
Mar 3, 2018·Hormone Molecular Biology and Clinical Investigation·Pedro-Antonio RegidorRene Druckman
Jan 10, 2012·European Journal of Endocrinology·Gabriella DonàDecio Armanini
Jan 23, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·P G ArtiniV Cela

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