PMID: 2501812Jan 1, 1989Paper

Effects of D2 dopamine receptor blockade with raclopride on intracranial self-stimulation and food-reinforced operant behaviour

Psychopharmacology
S Nakajima, J D Baker

Abstract

To examine the involvement of D2 dopamine receptors in the neural mechanism of reinforcement, raclopride tartrate, a D2 specific dopamine antagonist with a relatively fast central action, was injected into 32 rats. The D2 antagonist reduced bar-pressing responses reinforced with electrical stimulation of the ventral tegmental area (ED50 = 0.079 mumol/kg) and those reinforced with food (ED50 = 0.58 mumol/kg) in 18-30 min after IP injection. The reduction in response rates could not be attributed to an interference with motor functions. An increase in the frequency of brain-stimulation pulses and a change in the schedule of food reinforcement, which respectively increased the baseline rate of responding, did not alter the effectiveness of raclopride. SCH 23,390, a D1-specific dopamine antagonist, was sensitive to similar manipulation of reinforcement. These results seem to suggest that D1 and D2 antagonists may be acting at different locations in the neural mechanism underlying the reinforcement of operant behaviour.

References

Jul 19, 1978·Psychopharmacology·R A Yokel, R A Wise
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·S Nakajima, G M McKenzie

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Citations

May 1, 1992·Pharmacology, Biochemistry, and Behavior·S A McDougallA J Nonneman
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·P J Borg, D A Taylor
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·M A AguilarV M Simón
Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·C M Knapp, C Kornetsky
Oct 22, 2003·Physiology & Behavior·Daniel D Kurylo, Sarah Tanguay
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·S A JosselynR J Beninger
May 14, 1998·Neuroscience and Biobehavioral Reviews·R J Beninger, R Miller
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·K KitaM Takigawa
Feb 1, 1992·Pharmacology & Toxicology·D W Self, L Stein
Apr 5, 2007·Reviews in the Neurosciences·Mufida El-GhundiSusan R George
Jan 7, 2016·Frontiers in Behavioral Neuroscience·Giovanni Hernandez, Joseph F Cheer
Aug 25, 2004·Behavioural Brain Research·Daniel D Kurylo
Sep 12, 2006·Behavioural Brain Research·Christopher J Macdonald, Warren H Meck
Oct 3, 2006·Behavioural Brain Research·Dorothée Domenger, Rainer K W Schwarting
Feb 27, 2003·The European Journal of Neuroscience·Mufida El-GhundiSusan R George
Jan 4, 2001·Japanese Journal of Pharmacology·T Yamamoto, K Takada
Mar 1, 1994·Journal of the Experimental Analysis of Behavior·S B Caine, G F Koob

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