PMID: 9438882Aug 1, 1997Paper

Effects of daily melatonin administration on circadian activity rhythms in the diurnal Indian palm squirrel (Funambulus pennanti)

Journal of Biological Rhythms
S M Rajaratnam, J R Redman

Abstract

Exogenous melatonin induces phase shifts in circadian rhythms according to a phase response curve in nocturnal rodents, several nonmammalian diurnal species, and humans. Daily administration of melatonin entrains rhythms within a narrow circadian window of sensitivity in these species. Entrainment to exogenous melatonin has not previously been demonstrated in a (nonhuman) diurnal mammal. The authors examined the effects of daily melatonin administration (via food) in the diurnal Indian palm squirrel, Funambulus pennanti. The effects of melatonin or vehicle were examined at two times of day: zeitgeber time 0 (ZT 0: light onset time) and ZT 12 (dark onset time). In addition to melatonin- and vehicle-treated squirrels, there was a third group of squirrels that received no treatment. Squirrels were held initially under 12:12 light-dark (LD) cycles, and melatonin (1 mg/kg) or vehicle was administered in food (a raisin) at either ZT 0 or ZT 12 for a total of 17 days. On the third day of treatment, constant lighting (LL) was imposed. Treatment continued at the same ZTs for a further 14 days. The number of days before free-running commenced under constant conditions was assessed for squirrels in each treatment group. Results showed tha...Continue Reading

References

Oct 1, 1992·Chronobiology International·A J LewyR L Sack
Jan 1, 1991·Journal of Biological Rhythms·R L SackL D Keith
Nov 22, 1991·Brain Research·A J McArthurR A Prosser
Oct 15, 1989·Experientia·S M Armstrong
Mar 1, 1989·Endocrinology·J T LaitinenJ M Saavedra
Jan 1, 1986·Journal of Biological Rhythms·J Aschoff, H Tokura
Oct 16, 1987·Neuroscience Letters·V M CassoneR Y Moore
Jan 1, 1986·Journal of Pineal Research·H Underwood
Aug 1, 1985·Physiology & Behavior·H Underwood, M Harless
Jan 1, 1993·Journal of Biological Rhythms·W S WarrenV M Cassone
Jun 1, 1996·Journal of Biological Rhythms·S Benloucif, M L Dubocovich
Jan 1, 1960·Cold Spring Harbor Symposia on Quantitative Biology·J ASCHOFF

❮ Previous
Next ❯

Citations

Jan 10, 1998·Physiology & Behavior·S M Rajaratnam, J R Redman
May 1, 1999·Physiology & Behavior·S M Rajaratnam, J R Redman
Feb 15, 2000·Pharmacology, Biochemistry, and Behavior·T J Baird, D Gauvin
Jun 19, 1998·British Journal of Sports Medicine·J WaterhouseG Atkinson
Jul 30, 2008·Journal of Biological Rhythms·Helen J Burgess, Charmane I Eastman
Nov 5, 2013·Chronobiology International·Dhanananajay Kumar, Muniyandi Singaravel
Jun 23, 2007·Journal of Clinical Nursing·Magfiret Kara
Feb 18, 2011·Pediatric Blood & Cancer·Jennifer N StinsonAnja Koekebakker Low
Mar 30, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Pamela A Lopez-VargasJonathan C Craig
Dec 24, 1997·Journal of Biological Rhythms·J R Redman
Mar 15, 2001·Chronobiology International·S M Rajaratnam, J R Redman
Feb 14, 2002·Journal of Pineal Research·Anna Wirz-JusticeKurt Kräuchi
May 1, 2020·Chronobiology International·Sanjeev Kumar SoniMuniyandi Singaravel
Dec 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M Novak, H E Albers
Oct 13, 2020·Chronobiology International·Dhanananajay KumarMuniyandi Singaravel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.