PMID: 11927675Apr 3, 2002Paper

Effects of daily spontaneous running on the electrophysiological properties of hindlimb motoneurones in rats

The Journal of Physiology
Eric Beaumont, P F Gardiner

Abstract

No evidence currently exists that motoneurone adaptations in electrophysiological properties can result from changes in the chronic level of neuromuscular activity. We examined, in anaesthetized (ketamine/xylazine) rats, the properties of motoneurones with axons in the tibial nerve, from rats performing daily spontaneous running exercise for 12 weeks in exercise wheels ('runners') and from rats confined to plastic cages ('controls'). Motoneurones innervating the hindlimb via the tibial nerve were impaled with sharp glass microelectrodes, and the properties of resting membrane potential, spike threshold, rheobase, input resistance, and the amplitude and time-course of the afterhyperpolarization (AHP) were measured. AHP half-decay time was used to separate motoneurones into 'fast' (AHP half-decay time < 20 ms) and 'slow' (AHP half-decay time >/= 20 ms), the proportions of which were not significantly different between controls (58 % fast) and runners (65 % fast). Two-way ANOVA and ANCOVA revealed differences between motoneurones of runners and controls which were confined to the 'slow' motoneurones. Specifically, runners had slow motoneurones with more negative resting membrane potentials and spike thresholds, larger rheobasic sp...Continue Reading

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Citations

Sep 1, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Phillip GardinerBruno Cormery
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marin ManuelDaniel Zytnicki
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Jan 28, 2003·Muscle & Nerve·Eric Beaumont, Phillip F Gardiner
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May 5, 2006·Exercise and Sport Sciences Reviews·Phillip F Gardiner

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