PMID: 8941547Nov 1, 1996Paper

Effects of DAP on diaphragm force and fatigue, including fatigue due to neurotransmission failure

Journal of Applied Physiology
E van LUNTEREN, M Moyer

Abstract

Among the aminopyridines, 3,4-diaminopyridine (DAP) is a more effective K+ channel blocker than is 4-aminopyridine (4-AP), and, furthermore, DAP enhances neuromuscular transmission. Because 4-AP improves muscle contractility, we hypothesized that DAP would also increase force and, in addition, ameliorate fatigue and improve the neurotransmission failure component of fatigue. Rat diaphragm strips were studied in vitro (37 degrees C). In field-stimulated muscle, 0.3 mM DAP significantly increased diaphragm twitch force, prolonged contraction time, and shifted the force-frequency relationship to the left without-altering peak tetanic force, resulting in increased force at stimulation frequencies < or = 50 Hz. During 20-Hz intermittent stimulation, DAP increased diaphragm peak force compared with control during a 150-s fatigue run and, furthermore, significantly improved maintenance of intratrain force. The relative contribution of neurotransmission failure to fatigue was estimated by comparing the force generated by phrenic nerve-stimulated muscles with that generated by curare-treated field-stimulated muscles. DAP significantly increased force in nerve-stimulated muscles and, in addition, reduced the neurotransmission failure con...Continue Reading

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Citations

Sep 25, 2003·Physiological Reviews·Torben Clausen
Apr 27, 2004·Journal of Applied Physiology·Erik van LunterenHenry J Kaminski
Aug 4, 1998·Journal of Applied Physiology·E Van LunterenA Torres
Jul 13, 2002·Muscle & Nerve·Erik van Lunteren, Michelle Moyer
May 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ashok K DuaCoral L Murrant
Mar 6, 1999·Journal of Applied Physiology·E van Lunteren, M Moyer
Dec 22, 1999·Journal of Neurophysiology·M Moyer, E van Lunteren
Mar 17, 2007·The Journal of Physiology·Marika L ArmstrongCoral L Murrant
Jan 13, 2010·Journal of Neuroengineering and Rehabilitation·Erik van Lunteren, Jennifer Pollarine
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·E van LUNTEREN, M Moyer
Apr 22, 2003·Journal of Applied Physiology·Erik Van Lunteren, Michelle Moyer
Nov 24, 1999·Respiration Physiology·E van Lunteren, R M Snajdar
Mar 8, 2011·Annals of Physical and Rehabilitation Medicine·S Boyas, A Guével

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