Effects of dark maintenance on retinal biochemistry and function during taurine depletion in the adult rat

Visual Neuroscience
S E Cocker, N Lake

Abstract

Light dependence of the effects of taurine depletion on retinal function and biochemistry was examined in albino rats housed either in cyclic lighting or in continuous darkness. Measurements of retinal taurine, DNA, and rhodopsin contents, and electroretinogram amplitudes were made at weekly intervals. Naka-Rushton parameters were estimated for the b wave amplitude-intensity function. No significant effects of lighting regime were observed on retinal taurine levels in untreated rats, or on the time course or extent of taurine depletion in animals treated with guanidinoethyl sulfonate, an antagonist of taurine transport. In both lighting schemes, treatment led to a linear reduction of retinal taurine content which plateaued after 5-6 weeks at 50% of control despite continued treatment. DNA values did not differ among groups, whereas rhodopsin levels doubled in both groups of dark-maintained rats. For treated rats housed in cyclic lighting, the onset of electroretinogram deficits paralleled the loss of retinal taurine in the absence of changes in rhodopsin levels or cell death. Vmax was significantly reduced after 4 weeks of treatment. In contrast, for rats housed in continuous darkness, there were no significant differences in e...Continue Reading

References

Sep 1, 1977·Experimental Eye Research·M J VoadenB Morjaria
Feb 1, 1989·Current Eye Research·N Lake, C Verdone-Smith
Jan 1, 1988·Vision Research·N LakeL De Marte
Jan 1, 1988·Experimental Eye Research·O QuesadaH Pasantes-Morales
Mar 1, 1987·Experimental Eye Research·N Lake, N Malik
Jul 1, 1986·Experimental Eye Research·H Pasantes-MoralesP Pacheco
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·L A RentschlerM H Stipanuk
Jan 17, 1985·The New England Journal of Medicine·H S GeggelJ D Kopple
Sep 1, 1985·The British Journal of Nutrition·R P GuptaR K Gupta
Apr 1, 1968·Vision Research·A C Cornwell, S K Sharpless
Jul 1, 1983·Neurochemical Research·N Lake
Nov 1, 1982·Neurochemical Research·N Lake
Aug 1, 1961·The Biochemical Journal·G N WILKINSON
Nov 1, 1961·Experimental Cell Research·E RASCHK L CHOW

❮ Previous
Next ❯

Citations

Feb 6, 2009·Annals of Neurology·Firas JammoulSerge Picaud
Apr 12, 2014·Progress in Retinal and Eye Research·Nicolas FrogerSerge Picaud
May 10, 2002·Nutritional Neuroscience·Julius D Militante, John B Lombardini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.