Effects of dazoxiben and low-dose aspirin on platelet behaviour in man

British Journal of Clinical Pharmacology
E W JonesS Heptinstall

Abstract

1 We have studied the effects on platelet behaviour of ingestion of the thromboxane synthetase inhibitor dazoxiben (UK 37248), by healthy subjects, and compared the results with the effects of a low dose of aspirin (a cyclo-oxygenase inhibitor), and of a combination of dazoxiben and a low dose of aspirin. 2 Dazoxiben ingestion prevented the release reaction induced by sodium arachidonate (NaAA) in platelet-rich plasma (PRP) from some individuals ("responders") but not in PRP from others ("non-responders"). In vitro testing of PRP from the same subjects, incubated with 10(-4)M dazoxiben, correlated with the effect of dazoxiben ingestion on NaAA-induced release. Platelets from "non-responders" tended to undergo a more extensive release reaction than platelets from "responders" even in the absence of any drug although there was some overlap between the results in the two groups. Platelets from "non-responders" required significantly lower concentrations of NaAA to induce release reaction than platelets from "responders". Platelets from "responders" and "non-responders" did not differ in the amount of malondialdehyde (MDA) produced or in the effectiveness with which dazoxiben ingestion inhibited MDA production. 3 Low dose aspirin h...Continue Reading

References

Dec 1, 1979·British Journal of Haematology·G Di MinnoG de Gaetano
Apr 13, 1968·Lancet·J R O'Brien
Feb 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·M B Zucker, J Peterson
Sep 1, 1968·The Journal of Clinical Investigation·H J WeissS Kochwa
May 16, 1981·Lancet·J VermylenM Verstraete
Feb 21, 1981·British Medical Journal·J R Mitchell

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