Effects of decapeptide of mammalian bombesin and neuromedin B on pancreatic exocrine secretion in the rat

Digestion
M NambaS R Bloom

Abstract

The effects on pancreatic exocrine secretion of intravenous bolus injections of decapeptide of mammalian bombesin (also called neuromedin C) and neuromedin B, recently isolated mammalian bombesin-like peptides, have been studied and compared with those of amphibian bombesin in anaesthetized rats. Decapeptide of mammalian bombesin and neuromedin B stimulated the volume output from the pancreas with the same potency as that with which they stimulated protein output, as did amphibian bombesin. The maximal peak rates of volume and protein secretion observed in the 5- to 10-min period after the injection of 3 X 10(-10) mol/kg decapeptide of mammalian bombesin were 24.5 +/- 1.2 microliters/5 min and 8.5 +/- 0.5 mg bovine serum albumin equivalents per 5 min (mean +/- SEM, n = 5). These rates were equivalent to those produced by the same dose of amphibian bombesin, but the duration of responses to decapeptide of mammalian bombesin were shorter than those of equimolar doses of amphibian bombesin. The relative potencies of decapeptide of mammalian bombesin and neuromedin B, calculated from the doses producing 50% of maximum effect on total responses, were, respectively, 100 and 0.5% of that of amphibian bombesin. The results suggest that...Continue Reading

Citations

Sep 3, 1993·Regulatory Peptides·H Plamondon, Z Merali
Jun 7, 2000·Progress in Neurobiology·H Ohki-Hamazaki
Jan 1, 1988·Annals of the New York Academy of Sciences·J DominS R Bloom
Jan 1, 1988·Annals of the New York Academy of Sciences·L H LazarusH Yajima
Oct 1, 1992·The American Journal of Physiology·J PinskiA V Schally
Aug 1, 1989·The American Journal of Physiology·H MukaiE Munekata

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