Effects of decreased availability of sulfur amino acids in severe childhood undernutrition.

Nutrition Reviews
F Jahoor

Abstract

In studies of glutathione (GSH) metabolism in children with severe childhood undernutrition (SCU), slower erythrocyte GSH synthesis in children with edema was associated with lower concentrations of cysteine, the rate-limiting precursor of GSH synthesis. This finding suggested a shortage of cysteine available for GSH synthesis in children with edematous SCU. The plasma concentration of methionine, the sulfur donor for cysteine synthesis, was also lower in children with edematous SCU, suggesting decreased availability of methionine for cysteine synthesis. It is also possible that reduced methionine availability will result in decreased synthesis of S-adenosylmethionine, which could lead to an overall defect in methylation reactions. This review focuses on the relationship between cysteine availability and GSH synthesis in children with SCU. It also examines whether there is an inadequate supply of cysteine in those with edematous SCU and, if so, whether this is due to a shortage of methionine due to a decreased release of methionine from protein breakdown. Finally, the review explores whether a shortage of methionine results in decreased synthesis of S-adenosylmethionine, the universal methyl donor.

References

Jul 1, 1992·Journal of the Neurological Sciences·J S Chopra, A Sharma
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·A A Jackson
Feb 1, 1987·The Proceedings of the Nutrition Society·M H Golden, D Ramdath
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G VenturiniB Fontana
Sep 1, 1968·The American Journal of Clinical Nutrition·O BrunserI Contreras
Aug 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·W E Roediger
May 29, 1998·The Journal of Pediatrics·H LenhartzM Leichsenring
Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·M ReidF Jahoor
May 19, 2000·Journal of Pediatric Gastroenterology and Nutrition·B L NicholsF R Carrazza
Sep 2, 2000·The Journal of Pediatrics·M J ManaryJ W Heinecke
Feb 28, 2002·The American Journal of Clinical Nutrition·Neil R GibsonAlan A Jackson
Aug 29, 2002·The American Journal of Clinical Nutrition·Asha BadalooFarook Jahoor
Aug 1, 1956·A.M.A. Journal of Diseases of Children·D W ANDERSONH W HOWARD
Mar 19, 1960·Lancet·J C EDOZIENW R COLLIS
Jul 11, 2006·The American Journal of Clinical Nutrition·Farook JahoorTerrence Forrester
Dec 13, 2006·The American Journal of Clinical Nutrition·Farook JahoorTerrence Forrester
Dec 13, 2006·The American Journal of Clinical Nutrition·Farook JahoorTerrence Forrester

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Citations

Mar 1, 2012·Nutrition Reviews·Glenda Courtney-MartinPaul B Pencharz
Mar 26, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·S HeilskovM S Deleuran
May 31, 2020·Journal of Clinical Medicine·Martina Palomino-SchätzleinJosé Raúl Herance
May 9, 2021·The American Journal of Clinical Nutrition·Merry C FitzpatrickDaniel G Maxwell

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