Abstract
Decylubiquinone treatment in vitro has demonstrated a potent inhibitor effect on reactive oxidative species production. However, the effectin vivo has not been demonstrated yet. Thus, rats SHRSP male were divided in two groups: treated and controls (n=6, each). The treated group received 10 mg/Kg(-)/body weight of decylubiquinone diluted in coconut oil by oral gavage during four weeks. Control rats just received the vehicle. Body weight, diuresis, food and water intake, systolic blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, blood glucose levels and malondialdehyde were determined. There were a significant (p<0.05) reduction on systolic blood pressure, plasma malondialdehyde, total cholesterol and LDL-cholesterol in the treated group. Additionally, HDL-cholesterol also increased significantly. However, body weight, diuresis, food and water intake, blood glucose levels and triglycerides did not alter after treatment. Thus, decylubiquinone can be a new antihypertensive, hypolipidemic and antioxidant agent on the prevention and treatment of diseases linked to oxidative stress.
References
Apr 1, 1991·Biochemical Medicine and Metabolic Biology·H OkamotoH Yasuda
Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·M R McCallT M Forte
Dec 24, 1997·Hypertension·M McIntyreA F Dominiczak
Sep 25, 1998·The Journal of Biological Chemistry·E FontaineP Bernardi
Jul 13, 2000·The Journal of Biological Chemistry·L WalterE Fontaine
Oct 18, 2000·FEBS Letters·S MartinucciM Zoratti
Jun 26, 2002·Biological & Pharmaceutical Bulletin·Akihiro MichiharaHiroshi Tsuji
Oct 3, 2002·Molecular Genetics and Metabolism·Vanna GeromelPierre Rustin
Sep 2, 2003·The Journal of Biological Chemistry·Jeffrey S ArmstrongDean P Jones
Mar 27, 2004·Biochemical and Biophysical Research Communications·Jean-Jacques BrièrePierre Rustin
Feb 9, 2005·Hypertension·Martin W McBrideAnna F Dominiczak
May 17, 2005·Atherosclerosis·Domenico Praticò
Jan 3, 2006·Biological Trace Element Research·Ketan ModiP A Bhatt
Mar 15, 2006·Current Opinion in Anaesthesiology·Dipak K Das, Nilanjana Maulik
May 27, 2006·Cardiovascular & Hematological Disorders Drug Targets·Lai Ming YungYu Huang
Apr 6, 2007·Molecular and Cellular Biochemistry·Ramón RodrigoWalter Passalacqua
Apr 25, 2007·Apoptosis : an International Journal on Programmed Cell Death·Martin OttBoris Zhivotovsky
Citations
Aug 5, 2009·Antioxidants & Redox Signaling·William I Sivitz, Mark A Yorek
Jun 17, 2014·Journal of Diabetes and Metabolic Disorders·Md Ashraful Alam, Md Mahbubur Rahman
Jun 21, 2011·The Journal of Nutritional Biochemistry·Kun-Ling TsaiShih-Hwa Chiou
Jul 28, 2011·BioFactors·Leonardo Borges MuradLucia Marques Vianna
Jul 28, 2016·Scientific Reports·Hong-Li GaoYu-Ming Kang
Feb 10, 2021·Antioxidants·Juan M Suárez-RiveroJosé A Sánchez-Alcázar