PMID: 15228215Jul 2, 2004Paper

Effects of defatted safflower seed extract and phenolic compounds in diet on plasma and liver lipid in ovariectomized rats fed high-cholesterol diets

Journal of Nutritional Science and Vitaminology
Sung-Hee ChoYoungsun Choi

Abstract

Six polyphenolic compounds were isolated from ethylacetate extract secondary to 80% ethanol extraction of defatted safflower seeds. They were categorized into three types: lignans, flavones and serotonin derivatives. Female Sprague-Dawley rats weighing 163.4 +/- 6.3 g were ovariectomized (Ovx) and fed either ethylacetate extract at a level of 1% (w/w) or three types of safflower polyphenolic compounds at a level of 200 mg/kg in a diet containing 0.5% (w/w) cholesterol for four wk. The sham and Ovx control groups were fed the same diet without safflower components. Plasma GOT and GPT levels did not differ among the six experimental groups. The plasma levels of total cholesterol were reduced in the four safflower groups by 20-30% as compared to the Ovx control. The plasma level of HDL-cholesterol was higher in the Ovx+ethylacetate extract group or appeared to be in the three Ovx+safflower polyphenolic groups than in the Ovx control. The level of plasma triglyceride was also significantly lower in the Ovx+lignan group than in the Ovx control. The liver level of cholesterol was significantly reduced in the Ovx+ethylacetate extract group. Fecal excretion of cholesterol increased by the safflower lignans and flavones, whereas that of...Continue Reading

Citations

May 4, 2012·Clinical Oral Investigations·Christian HannigKlaus Kümmerer
Sep 15, 2009·The British Journal of Nutrition·Rosaria PigaToshikazu Yoshikawa
Dec 4, 2010·Vascular Health and Risk Management·Katsuya SuzukiKenji Takazawa
Aug 20, 2010·Journal of Oleo Science·Nagao TotaniHaruyasu Kida
Oct 5, 2010·Nutrition Reviews·Julia PetersonMarjorie L McCullough
Sep 26, 2015·International Journal of Food Sciences and Nutrition·Qingyu WangFazheng Ren
Jan 5, 2005·BioFactors·Sung-Hee ChoYoungsun Choi
Oct 25, 2011·Phytotherapy Research : PTR·Toshiyuki Takahashi, Mitsuo Miyazawa
Apr 16, 2016·The American Journal of Chinese Medicine·Le-Le ZhangJin-Jian Lu
Aug 19, 2008·Menopause : the Journal of the North American Menopause Society·Sun Hee DoKyu-Shik Jeong
Apr 8, 2020·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Niti PathakSuman Lakhanpaul
Apr 4, 2017·Journal of Neuro-oncology·Diamanto LazariAthanasios P Kyritsis
Oct 11, 2017·Journal of Agricultural and Food Chemistry·Xing-Rong PengMing-Hua Qiu

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