Effects of defibrillation shock in patients implanted with a subcutaneous defibrillator: a biomarker study

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Antonio D'OnofrioGerardo Nigro

Abstract

Implantable cardioverter defibrillator (ICD) shocks are associated with a subsequent increased risk of death, and an elevation of cardiac enzymes has been measured after defibrillation testing (DFT). In an experimental swine study, subcutaneous ICD (S-ICD) shocks caused less myocardial damage than traditional ICD shocks. The aim of our study was to investigate the association between S-ICD shock and acute cardiac damage in humans, as evaluated by means of sensitive and highly specific circulating biomarkers. We calculated the variation in the serum levels of high-sensitivity cardiac troponin I (hs-CTnI) and creatine kinase-MB mass concentration (CK-MB mass), measured before and after an S-ICD shock delivered during intraoperative DFT. We also measured the degree of haemodynamic stress, as the variation in the serum levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and copeptin (CP), after the S-ICD shock. We analysed 30 consecutive patients who received an S-ICD and who underwent DFT by means of a single 65 J shock. The levels of biomarkers did not change from baseline to 1 h post-shock, i.e. hs-CTnI (from 0.029 ± 0.005 ng/mL to 0.030 ± 0.005 ng/mL, P = 0.079) and CK-MB mass (from 1.37 ± 0.17 ng/mL to 1.41 ± 0.18,...Continue Reading

References

Sep 4, 1998·Journal of Cardiovascular Electrophysiology·T TokanoS A Strickberger
Aug 10, 1999·Journal of the American College of Cardiology·T M HurstB Waldecker
Oct 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Akio OgawaTeruo Takano
Apr 10, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Cihan CevikKenneth Nugent
Jan 11, 2011·International Journal of Cardiology·Kenan YaltaErtan Yetkın
May 26, 2011·JAMA : the Journal of the American Medical Association·Urban AlehagenJens P Goetze
Dec 1, 2011·Pacing and Clinical Electrophysiology : PACE·Charles K FrancisSteven Daniels
Jan 24, 2012·European Heart Journal·Raphael TwerenboldChristian Mueller
Nov 21, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bruce L WilkoffUNKNOWN Document Reviewers
Dec 25, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giovanni Luca BottoUNKNOWN ‘AIAC S-ICD Why Not’ Survey Investigators
May 2, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Rodrigue GarciaBruno Degand

❮ Previous
Next ❯

Citations

Mar 13, 2019·Journal of the American Heart Association·Yitschak BitonIlan Goldenberg
Aug 12, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·W van der StuijtR E Knops
Apr 30, 2020·Critical Care : the Official Journal of the Critical Care Forum·Joachim DüringNiklas Nielsen
Sep 23, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Severin WeigandChristof Kolb

❮ Previous
Next ❯

Software Mentioned

SPSS
LOCI

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Guy FurnissPeter D Larsen
© 2022 Meta ULC. All rights reserved