Effects of deficiencies in the engrailed region of Drosophila melanogaster

Developmental Biology
S Eberlein, M A Russell

Abstract

The engrailed gene of Drosophila melanogaster is believed to be involved in control of determination and differentiation of posterior compartments. en1/en1 causes a partial transformation of the posterior compartment of wing and first leg to mirror-image anterior, which prompted the hypothesis that engrailed + is a "selector gene" required for the posterior pathway decision. The incomplete transformation was thought due to residual en+ activity in en1; a deletion of engrailed (en28) was constructed to determine if a complete transformation can occur. en28 is homozygous lethal and cell lethal. en28/en1 survives to adult stage, but causes a weaker transformation than en1/en1, indicating that en1 is not a simple hypomorph. A more distal deletion, en30, survives over en-lethal alleles. Both en30/en1 and en28/en30 survive to adult stage, but do not cause a stronger posterior to anterior transformation than en1/en1; thus this effect may be allele specific. New abnormalities included (1) transformation of the posterior wing blade to haltere, an effect dependent on the bx+ (but not pbx+) pseudoallele of the bithorax complex; (2) abnormal bristle pattern, tarsal fusion, and degenerate posterior claws of all legs. Although these abnormal...Continue Reading

References

Jun 1, 1979·Developmental Biology·G Morata, P A Lawrence
Jun 1, 1976·Developmental Biology·E Wieschaus, W Gehring
Jan 1, 1976·Developmental Biology·A Garcia-BellidoG Morata
Jun 1, 1976·Developmental Biology·P A Lawrence, G Morata
Oct 1, 1969·Journal of Theoretical Biology·L Wolpert
Oct 24, 1973·Nature: New Biology·A Garcia-BellidoG Morata
Jan 1, 1971·Current Topics in Developmental Biology·L Wolpert
Dec 1, 1983·Developmental Biology·F Epper, L Sánchez
Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Feb 1, 1982·Genetics·D Thierry-Mieg
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T Kornberg
Oct 1, 1981·Cell·P A Lawrence
Mar 1, 1976·Wilhelm Roux's Archives of Developmental Biology·Emil Steiner

❮ Previous
Next ❯

Citations

Dec 1, 1983·Developmental Biology·F Epper, L Sánchez
Dec 28, 2002·Genome Génome / Conseil National De Recherches Canada·Ajay SrivastavaJohn B Bell
Oct 24, 1997·Nature·B S Emerald, J K Roy
Jul 1, 1985·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B C Goodwin
Nov 1, 1995·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Jyoti BhojwaniPradip Sinha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.