Effects of definitive and salvage radiotherapy on the distribution of lymphocyte subpopulations in prostate cancer patients

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Eva K SageGabriele Multhoff

Abstract

Radiotherapy (RT) is an established treatment for patients with primary and recurrent prostate cancer. Herein, the effects of definitive and salvage RT on the composition of lymphocyte subpopulations were investigated in patients with prostate cancer to study potential immune effects. A total of 33 prostate cancer patients were treated with definitive (n = 10) or salvage RT (n = 23) after biochemical relapse. The absolute number of lymphocytes and the distribution of lymphocyte subpopulations were analyzed by multiparameter flow cytometry before RT, at the end of RT, and in the follow-up period. Absolute lymphocyte counts decreased significantly after RT in both patient groups and a significant drop was observed in the percentage of B cells directly after RT from 10.1 ± 1.3 to 6.0 ± 0.7% in patients with definitive RT and from 9.2 ± 0.8 to 5.8 ± 0.7% in patients with salvage RT. In contrast, the percentages of T and natural killer (NK) cells remained unaltered directly after RT in both patient groups. However, 1 year after RT, the percentage of CD3(+) T cells was significantly lower in patients with definitive and salvage RT. The percentage of regulatory T cells was slightly upregulated in primary prostate cancer patients after...Continue Reading

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Citations

Mar 4, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Michael RückertUdo S Gaipl
Nov 6, 2018·Oncoimmunology·Franziska EckertCécile Gouttefangeas
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May 11, 2021·Frontiers in Oncology·Jonathan KhalifaElizabeth Cohen-Jonathan Moyal
Jul 1, 2020·Combinatorial Chemistry & High Throughput Screening·Yaojian JinMingxing Ding

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