PMID: 6712332Apr 1, 1984

Effects of delay in administration of potassium cardioplegia to the isolated rat heart

The Annals of Thoracic Surgery
B M FreedmanA S Wechsler


Ischemic injury to the heart in the period between aortic cross-clamping and administration of cardioplegic solution was evaluated in the normothermic rat heart model. After isolation and control perfusion with oxygenated Krebs-Henseleit bicarbonate buffer, the hearts were given lactated Ringer's cardioplegic solution (30 mEq of K+ per liter) for 2 minutes at three different intervals following aortic clamping: no delay, 2-minute delay, and 5-minute delay. Thereafter, the hearts were left unperfused and the time to initiation of ischemic contracture was recorded. Adenosine triphosphate (ATP) and creatine phosphate levels were measured in all groups prior to and at the conclusion of cardioplegia administration. A 2-minute delay in the administration of cardioplegic solution resulted in significantly lower (p less than 0.001) ATP levels that were restored after 2 minutes of cardioplegia administration. Contracture times were not significantly altered. A 5-minute delay resulted in significantly shorter (p less than 0.001) contracture times and significantly lower (p less than 0.001) ATP levels that were not restored to preischemic levels by 2 minutes of cardioplegia administration. The fate of the myocardium may be insensitive to ...Continue Reading


Jun 1, 1977·The American Journal of Cardiology·D J HearseS M Humphrey
Dec 1, 1974·The Journal of Clinical Investigation·R A KlonerR B Jennings
Sep 1, 1968·The American Journal of Cardiology·A Wollenberger, E G Krause
Sep 1, 1968·The American Journal of Cardiology·W LochnerE R Müller-Ruchholtz

Related Concepts

Potassium crystalloid cardioplegia
Adenosine Triphosphate, Chromium Ammonium Salt
Coronary Circulation
Coronary Heart Disease
Pulse Rate
Myocardial Contraction

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